View : 44 Download: 0

Evaluation of antibodies against Haemophilus influenzae type b in Korean adults

Title
Evaluation of antibodies against Haemophilus influenzae type b in Korean adults
Authors
Lee J.H.Kim H.W.Lee S.Kim K.-H.
Ewha Authors
김경효김한울
SCOPUS Author ID
김경효scopus; 김한울scopus
Issue Date
2017
Journal Title
Pediatric Infection and Vaccine
ISSN
2384-1079JCR Link
Citation
Pediatric Infection and Vaccine vol. 24, no. 3, pp. 125 - 133
Keywords
AdultAgedAntibodiesHaemophilus influenzae type b
Publisher
The Korean Society of Pediatric Infectious Diseases
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
Purpose: After the introduction of Haemophilus influenzae type b (Hib) vaccine in 1995 in Korea, it was included in the national immunization program in 2013. In the post-Hib vaccine era, some studies in other countries reported that invasive Hib disease affects adults, especially the elderly and immunocompromised persons, more often than it affects children. To evaluate disease susceptibility, quantitative and qualitative analysis of anti-polyribosylribitol phosphate (PRP) antibodies were carried out in Korean adults aged 20 to 85 years. Methods: Sera were collected from 39 healthy adults (20 to 50 years of age) and from 30 elderly adults (75 to 85 years of age) who did not have immune-compromising conditions. The concentration of anti-PRP immunoglobulin G (IgG) and serum bactericidal indices (SBIs) were measured by enzyme-linked immunosorbent assay and serum bactericidal assay. Results: Geometric mean concentrations of anti-PRP IgG and geometric mean SBIs were 0.88 μg/mL (95% confidence interval [CI], 0.17 to 3.85) and 354 (95% CI, 50 to 2,499) in young adults and 1.67 μg/mL (95% CI, 0.53 to 5.24) and 449 (95% CI, 146 to 1,376) in elderly adults, respectively. When the threshold of seropositivity for anti-PRP IgG was applied as 0.15 or 1.0 μg/mL, which is the protective antibody level in children, seropositive rates were 87.2% or 53.8% in young adults and 100% or 60% in elderly adults. The seropositivity rates of the SBI (SBI ≥4) were 82.1% and 100% in the groups, respectively. Conclusions: Most subjects in the adult and elderly adult groups display immunity to Hib based on quantitative and qualitative antibody levels, but not all. Because high immunization and low Hib circulation rates may reduce the natural Hib immunity in the population, monitoring Hib immunity as well as disease are needed continuously. © 2017, The Korean Society of Pediatric Infectious Diseases. All rights reserved.
DOI
10.14776/piv.2017.24.3.125
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE