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Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence

Title
Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence
Authors
Park, ShinwonJung, Jiyoung J.Kang, IlhyangLee, Boung ChulLee, Suji L.Ma, JiyoungKim, JungyoonCho, Han ByulJeong, Hyeonseok S.Lim, Soo MeeHong, Young SunChoi, Ihn-GeunKim, Jieun E.
Ewha Authors
홍영선임수미김지은김정윤
SCOPUS Author ID
홍영선scopus; 임수미scopus; 김지은scopus; 김정윤scopus
Issue Date
2018
Journal Title
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
ISSN
1557-1874JCR Link

1557-1882JCR Link
Citation
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION vol. 16, no. 4, pp. 946 - 955
Keywords
Alcohol dependenceCaudate nucleusCarbohydrate-deficient transferrinStructural magnetic resonance imagingSemi-automated segmentationBrain volume
Publisher
SPRINGER
Indexed
SCIE; SSCI; SCOPUS WOS scopus
Document Type
Article
Abstract
The caudate nucleus has shown a high relevance with substance craving and addiction in the pathophysiology of alcohol dependence. In this study, caudate volumetric deficits in patients with alcohol dependence and their associations with carbohydrate-deficient transferrin (CDT), a biomarker of chronic alcohol consumption, were evaluated in 21 patients with alcohol dependence and age- and sex-matched 21 healthy comparison subjects. Between-group difference in caudate volumes and correlations between CDT and caudate volumes in the patient group were examined after adjusting for age, sex, and intracranial volume. Volumetric analysis results show prominent abnormalities in the left caudate among patients with alcohol dependence (z = - 2.70, p = 0.007). CDT levels significantly predicted volumetric deficits in the left caudate (beta = - 1.23, p = 0.003). These findings suggest that the caudate nucleus may be one of the important brain regions related to alcohol-induced chronic brain damages.
DOI
10.1007/s11469-017-9803-6
Appears in Collections:
의과대학 > 의학과 > Journal papers
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