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Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence
- Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence
- Park, Shinwon; Jung, Jiyoung J.; Kang, Ilhyang; Lee, Boung Chul; Lee, Suji L.; Ma, Jiyoung; Kim, Jungyoon; Cho, Han Byul; Jeong, Hyeonseok S.; Lim, Soo Mee; Hong, Young Sun; Choi, Ihn-Geun; Kim, Jieun E.
- Ewha Authors
- 홍영선; 임수미; 김지은; 김정윤
- SCOPUS Author ID
- 홍영선; 임수미; 김지은; 김정윤
- Issue Date
- Journal Title
- INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
- INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION vol. 16, no. 4, pp. 946 - 955
- Alcohol dependence; Caudate nucleus; Carbohydrate-deficient transferrin; Structural magnetic resonance imaging; Semi-automated segmentation; Brain volume
- SCIE; SSCI; SCOPUS
- Document Type
- The caudate nucleus has shown a high relevance with substance craving and addiction in the pathophysiology of alcohol dependence. In this study, caudate volumetric deficits in patients with alcohol dependence and their associations with carbohydrate-deficient transferrin (CDT), a biomarker of chronic alcohol consumption, were evaluated in 21 patients with alcohol dependence and age- and sex-matched 21 healthy comparison subjects. Between-group difference in caudate volumes and correlations between CDT and caudate volumes in the patient group were examined after adjusting for age, sex, and intracranial volume. Volumetric analysis results show prominent abnormalities in the left caudate among patients with alcohol dependence (z = - 2.70, p = 0.007). CDT levels significantly predicted volumetric deficits in the left caudate (beta = - 1.23, p = 0.003). These findings suggest that the caudate nucleus may be one of the important brain regions related to alcohol-induced chronic brain damages.
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