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Vaccination with a latch peptide provides serotypeindependent protection against group B streptococcus infection in mice

Title
Vaccination with a latch peptide provides serotypeindependent protection against group B streptococcus infection in mice
Authors
Lin S.-M.Jang A.-Y.Zhi Y.Gao S.Lim S.Lim J.H.Song J.Y.Sullam P.M.Rhee J.H.Seo H.S.
Ewha Authors
임재향
SCOPUS Author ID
임재향scopus
Issue Date
2018
Journal Title
Journal of Infectious Diseases
ISSN
0022-1899JCR Link
Citation
Journal of Infectious Diseases vol. 217, no. 1, pp. 93 - 102
Keywords
Latch; Serine-rich repeat; Streptococcus agalactiae; Vaccine
Publisher
Oxford University Press
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Streptococcus agalactiae (group B streptococcus [GBS]) is a leading cause of invasive diseases in neonates and severe infections in elderly individuals. GBS serine-rich repeat glycoprotein 1 (Srr1) acts as a critical virulence factor by facilitating GBS invasion into the central nervous system through interaction with the fbrinogen Aa chain. This study revealed that srr1 is highly conserved, with 86.7% of GBS clinical isolates expressing the protein. Vaccination of mice with different Srr1 truncated peptides revealed that only Srr1 truncates containing the latch domain protected against GBS meningiThis. Furthermore, the latch peptide alone was immunogenic and elicited protective antibodies, which efciently enhanced antibody-mediated opsonophagocytic killing of GBS by HL60 cells and provided heterogeneous protection against 4 different GBS serogroups. Taken together, these fndings indicated that the latch domain of Srr1 may constitute an effective peptide vaccine candidate for GBS. © The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
DOI
10.1093/infdis/jix565
Appears in Collections:
의과대학 > 의학과 > Journal papers
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