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Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/II NK/T-cell lymphoma
- Title
- Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/II NK/T-cell lymphoma
- Authors
- Kwong Y.L.; Kim S.J.; Tse E.; Oh S.Y.; Kwak J.Y.; Eom H.S.; Do Y.R.; Mun Y.C.; Lee S.R.; Shin H.J.; Suh C.; Chuang S.S.; Lee Y.S.; Lim S.T.; Izutsu K.; Suzuki R.; Relander T.; d'Amore F.; Schmitz N.; Jaccard A.; Kim W.S.
- Ewha Authors
- 문영철
- SCOPUS Author ID
- 문영철
- Issue Date
- 2018
- Journal Title
- Annals of Oncology
- ISSN
- 0923-7534
- Citation
- Annals of Oncology vol. 29, no. 1, pp. 256 - 263
- Keywords
- Concurrent chemoradiotherapy; Sequential chemotherapy and radiotherapy; Stage I/II NK/T-cell lymphomas
- Publisher
- Oxford University Press
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: In stage I/II natural killer (NK)/T-cell lymphoma, concurrent chemoradiotherapy (CCRT) had previously been shown to result in superior outcome compared with anthracycline-containing regimens, which have since been considered ineffective. The role of CCRT in comparison with approaches employing nonanthracycline-containing chemotherapy (CT) and sequential radiotherapy (RT) in such patients remains to be defined. Patients and methods: Three hundred and three untreated patients (207 men, 96 women; median age: 51, 18-86 years) with stage I/II NK/T-cell lymphoma who had received nonanthracycline-containing regimens were collected from an international consortium and retrospectively analyzed. Treatment included single modality (CT and RT), sequential modalities (CT+RT; RT+CT) and concurrent modalities (CCRT; CCRT+CT). The impact of clinicopathologic parameters and types of treatment on complete response (CR) rate, progression-free-survival (PFS) and overall-survival (OS) was evaluated. Results: For CR, stage (P=0.027), prognostic index for NK/T-cell lymphoma (PINK) (P=0.026) and types of initial treatment (P=0.011) were significant prognostic factors on multivariate analysis. On Cox regression analysis, ECOG performance score (P=0.021) and PINK-EBV DNA (PINK-E) (P=0.002) significantly impacted on PFS; whereas ECOG performance score (P=0.008) and stage (P<0.001) significantly impacted on OS. For comparing CCRT6CT and sequential CT+RT, CCRT6CT patients (n=190) were similar to sequential CT+RT patients (n=54) in all evaluated clinicopathologic parameters except two significantly superior features (higher proportion of undetectable circulating EBV DNA on diagnosis and lower PINK-E scores). Despite more favorable pre-treatment characteristics, CCRT6CT patients had CR rate, PFS and OS comparable with sequential CT+RT patients on multivariate and Cox regression analyses. Conclusions: In stage I/II NK/T-cell lymphomas, when effective chemotherapeutic regimens were used, CCRT and sequential CT+RT gave similar outcome. © The Author 2017.
- DOI
- 10.1093/annonc/mdx684
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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