Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희영 | * |
dc.contributor.author | 김휘영 | * |
dc.date.accessioned | 2018-11-21T16:30:45Z | - |
dc.date.available | 2018-11-21T16:30:45Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0192-0790 | * |
dc.identifier.other | OAK-22096 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/246851 | - |
dc.description.abstract | Background/Aims: In patients with early-stage hepatocellular carcinoma (HCC), selection of candidates for liver transplantation (LT) requires refinement based on tumor biology to maximize the outcome. We aimed to prognosticate LT candidates with HCC using a risk prediction model for post-LT recurrence. Patients and Methods: A total of 197 consecutive patients were included who underwent LT for hepatitis B-related HCC within the Milan criteria. A risk prediction model was developed for post-LT recurrence using the Cox model and was internally validated. Results: Among those undergoing LT as their first HCC treatment (n=70, initial LT group), poor prognosis was associated with maximal tumor size and multinodularity. The remaining 127 patients (deferred LT group) received radiofrequency ablation (n=69) and/or transarterial chemoembolization (n=98) before LT. Multinodularity, maximal tumor size, posttransarterial chemoembolization progressive disease, baseline alpha-fetoprotein, and alpha-fetoprotein difference (between baseline and pre-LT) were incorporated into a risk prediction model for the deferred LT group, which was thereby stratified into low-risk (score<5), intermediate-risk, and high-risk (score?8) subgroups. Recurrence-free survival was significantly different among the deferred LT prognostic subgroups (P<0.001). Conclusions: This risk prediction model may help refinement of ablate-and-wait strategy for LT candidates by avoiding LT in those with either high risk score at baseline or increasing score under repeated locoregional therapies. © 2017 Wolters Kluwer Health, Inc. All rights reserved. | * |
dc.description.sponsorship | Applied Scientific Research Fund | * |
dc.language | English | * |
dc.publisher | Lippincott Williams and Wilkins | * |
dc.subject | clinical decision making | * |
dc.subject | hepatocellular carcinoma | * |
dc.subject | transplantation | * |
dc.title | A Model for Adaptive Decision Making of 'Ablate-and-Wait' Versus Transplantation in Patients with Hepatocellular Carcinoma | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 52 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 655 | * |
dc.relation.lastpage | 661 | * |
dc.relation.journaltitle | Journal of Clinical Gastroenterology | * |
dc.identifier.doi | 10.1097/MCG.0000000000000981 | * |
dc.identifier.wosid | WOS:000439523600015 | * |
dc.identifier.scopusid | 2-s2.0-85041564240 | * |
dc.author.google | Kim H.Y. | * |
dc.author.google | Kim W. | * |
dc.author.google | Jung Y.J. | * |
dc.author.google | Lee J.-H. | * |
dc.author.google | Yu S.J. | * |
dc.author.google | Kim Y.J. | * |
dc.author.google | Yoon J.-H. | * |
dc.author.google | Lee H.W. | * |
dc.author.google | Kim H. | * |
dc.author.google | Yi N.-J. | * |
dc.author.google | Lee K.-W. | * |
dc.author.google | Suh K.-S. | * |
dc.contributor.scopusid | 김휘영(56493773500) | * |
dc.date.modifydate | 20240429140130 | * |