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Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy
- Title
- Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy
- Authors
- Chang J.H.; Shin K.H.; Ahn S.D.; Park H.J.; Chie E.K.; Kim J.H.; Kim S.S.; Kim Y.B.; Park W.; Kim Y.-J.; Shin H.S.; Lee S.Y.; Kim K.; Park K.R.; Jeong B.K.; Kim J.Y.; Kim S.
- Ewha Authors
- 김규보
- SCOPUS Author ID
- 김규보
- Issue Date
- 2018
- Journal Title
- Breast Cancer Research and Treatment
- ISSN
- 0167-6806
- Citation
- Breast Cancer Research and Treatment vol. 169, no. 3, pp. 507 - 512
- Keywords
- 1–3 positive nodes; Breast cancer; Chest wall irradiation; Chest wall recurrence risk factor; Post-mastectomy radiation therapy
- Publisher
- Springer New York LLC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose: In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT). Methods: The data from the patients participating in two South Korean multi-institutional studies (KROG 14–22; N = 1842 and KROG 14–23; N = 1382) were analyzed. In total, 3224 pT1-2N0-1 breast cancer patients who underwent mastectomy without PMRT were analyzed. Results: The median follow-up time was 72.2 months (range 0.8–125.2 months). The overall CWRs during the follow-up period were 1.68% in N0 patients and 2.82% in N1 patients. There was no statistically significant difference in 5-year and 10-year CWR-free survival (CWRFS) between the N0 and N1 patients. Of the 70 patients with CWR, 33 (1% of all the patients) had isolated CWR, and the 10-year overall survival rate in this group was 96.9%. After the propensity score matching of the N0 and N1 groups, there was still no difference in CWRFS by nodal status. Conclusions: The incidence of CWR in pT1-2N0-1 breast cancer patients is very low, especially with isolated recurrence. Also, the obtained data showed that the nodal status had no impact on CWRFS. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
- DOI
- 10.1007/s10549-018-4707-0
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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