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High blood neutrophil-lymphocyte ratio associated with poor outcomes in miliary tuberculosis

Title
High blood neutrophil-lymphocyte ratio associated with poor outcomes in miliary tuberculosis
Authors
Han Y.Kim S.J.Lee S.H.Sim Y.S.Ryu Y.J.Chang J.H.Shim S.S.Kim Y.Lee J.H.
Ewha Authors
장중현김유경이진화심성신류연주김수정이수환
SCOPUS Author ID
장중현scopus; 김유경scopus; 이진화scopus; 심성신scopus; 류연주scopus; 김수정scopus
Issue Date
2018
Journal Title
Journal of Thoracic Disease
ISSN
2072-1439JCR Link
Citation
Journal of Thoracic Disease vol. 10, no. 1, pp. 339 - 346
Keywords
Miliary tuberculosisNeutrophil-lymphocyte ratio (NLR)
Publisher
AME Publishing Company
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: It is difficult to predict the prognosis of miliary tuberculosis (TB). We hypothesized that blood neutrophil-lymphocyte ratio (NLR) is an indicator of inflammatory status to reflect independent prognostic significance in patients with miliary TB. The aim of this study is to investigate the relationship between NLR and outcome in miliary TB. Methods: We retrospectively collected data from patients diagnosed with miliary TB in a tertiary referral hospital between January 1995 and January 2016. Results: A total of 96 patients were enrolled. Seventeen patients (18%) died during hospitalization due to miliary TB, and 9 (9%) died additionally during the 1-year follow-up period. Eighteen patients (19%) were diagnosed with acute respiratory distress syndrome (ARDS). In multiple logistic regression analyses, increased NLR was associated with ARDS [adjusted odds ratio, 1.15; 95% confidence interval (CI), 1.03- 1.28]. By multivariate Cox regression analysis with adjustment of known prognostic factors including age, sex, body mass index, serum aspartate aminotransferase (AST), and hemoglobin, NLR was an independent predictor of in-hospital mortality [adjusted hazard ratio (aHR), 1.08; 95% CI, 1.03-1.13] and 1-year mortality (aHR, 1.08; 95% CI, 1.05-1.12). Conclusions: Pre-treatment NLR at admission may be a useful biomarker for mortality and development of ARDS in patients with miliary TB. © Journal of Thoracic Disease.
DOI
10.21037/jtd.2017.12.65
Appears in Collections:
의과대학 > 의학과 > Journal papers
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