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Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets

Title
Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets
Authors
Jeon S.H.Kim Y.P.Kho Y.Shin J.H.Ji W.H.Ahn Y.G.
Ewha Authors
김용표
SCOPUS Author ID
김용표scopus
Issue Date
2018
Journal Title
Journal of Analytical Methods in Chemistry
ISSN
2090-8865JCR Link
Citation
Journal of Analytical Methods in Chemistry vol. 2018
Publisher
Hindawi Limited
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
A method for the quantitative determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylhexyl) adipate (DEHA), bis(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), dioctyl terephthalate (DOTP), diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP) in medical infusion sets was developed and validated using gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) in the multiple reaction monitoring (MRM) mode. Solvent extraction with polymer dissolution for sample preparation was employed prior to GC-MS/MS analysis. Average recoveries of the eight target analytes are typically in the range of 91.8-122% with the relative standard deviations of 1.8-17.8%. The limits of quantification (LOQs) of the analytical method were in the ranges of 54.1 to 76.3 ng/g. Analysis using GC-MS/MS provided reliable performance, as well as higher sensitivity and selectivity than GC-MS analysis, especially for the presence of minority plasticizers at different concentrations. © 2018 So Hyeon Jeon et al.
DOI
10.1155/2018/9470254
Appears in Collections:
엘텍공과대학 > 화학신소재공학전공 > Journal papers
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