Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이수환 | - |
dc.date.accessioned | 2018-11-21T16:30:37Z | - |
dc.date.available | 2018-11-21T16:30:37Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-22232 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/246807 | - |
dc.description.abstract | Insulin-like growth factor-1 (IGF-1) levels are known to increase in the bronchoalveolar lavage fluid (BALF) of patients with acute respiratory distress syndrome. Herein, we investigated the role of IGF-1 in lipopolysaccharide (LPS)-induced lung injury. In LPS-treated cells, expressions of receptor-interacting protein 3 (RIP3) and phosphorylated mixed lineage kinase domain-like protein (MLKL) were decreased in IGF-1 receptor small interfering RNA (siRNA)-treated cells compared to control cells. The levels of pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, IL-10, tumour necrosis factor-α, and macrophage inflammatory protein 2/C-X-C motif chemokine ligand 2 in the supernatant were significantly reduced in IGF-1 receptor siRNA-treated cells compared to control cells. In LPS-induced murine lung injury model, total cell counts, polymorphonuclear leukocytes counts, and pro-inflammatory cytokine levels in the BALF were significantly lower and histologically detected lung injury was less common in the group treated with IGF-1 receptor monoclonal antibody compared to the non-treated group. On western blotting, RIP3 and phosphorylated MLKL expressions were relatively decreased in the IGF-1 receptor monoclonal antibody group compared to the non-treated group. IGF-1 may be associated with RIP3-mediated necroptosis in vitro, while blocking of the IGF-1 pathway may reduce LPS-induced lung injuries in vivo. © 2018 Elsevier Inc. | - |
dc.description.sponsorship | Yonsei University College of Medicine | - |
dc.language | English | - |
dc.publisher | Elsevier B.V. | - |
dc.subject | Adult | - |
dc.subject | IGF-1 receptor | - |
dc.subject | Lipopolysaccharide | - |
dc.subject | Lung injury | - |
dc.subject | Necroptosis | - |
dc.subject | Respiratory distress syndrome | - |
dc.title | Inhibition of insulin-like growth factor receptor-1 reduces necroptosis-related markers and attenuates LPS-induced lung injury in mice | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 498 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 877 | - |
dc.relation.lastpage | 883 | - |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.03.074 | - |
dc.identifier.wosid | WOS:000430158200027 | - |
dc.identifier.scopusid | 2-s2.0-85043532446 | - |
dc.author.google | Lee S.H. | - |
dc.author.google | Shin J.H. | - |
dc.author.google | Song J.H. | - |
dc.author.google | Leem A.Y. | - |
dc.author.google | Park M.S. | - |
dc.author.google | Kim Y.S. | - |
dc.author.google | Chang J. | - |
dc.author.google | Chung K.S. | - |
dc.contributor.scopusid | 이수환(36968744900) | - |
dc.date.modifydate | 20230208104911 | - |