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Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation
- Title
- Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation
- Authors
- Cho, Kyung-Ah; Park, Minhwa; Kim, Yu-Hee; Choo, Hea-Young Park; Lee, Kyung Ho
- Ewha Authors
- 박혜영; 조경아
- SCOPUS Author ID
- 박혜영; 박혜영; 조경아
- Issue Date
- 2018
- Journal Title
- MOLECULAR MEDICINE REPORTS
- ISSN
- 1791-2997
1791-3004
- Citation
- MOLECULAR MEDICINE REPORTS vol. 17, no. 5, pp. 6723 - 6730
- Keywords
- mast cells; benzoxazole derivatives; 5-lipoxygenase inhibitors; histamine; inflammation
- Publisher
- SPANDIDOS PUBL LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Mast cells are central regulators of allergic inflammation that function by releasing various proallergic inflammatory mediators, including histamine, eicosanoids and proinflammatory cytokines. Occasionally, bacterial infections may initiate or worsen allergic inflammation. A number of studies have indicated that activation of lipoxygenase in mast cells positive regulates allergic inflammatory responses by generating leukotrienes and proinflammatory cytokines. In the present study, the effects of benzoxazole derivatives on the lipopolysaccharide (LPS)-induced expression of proinflammatory cytokines, production of histamine and surface expression of co-stimulatory molecules on bone marrow-derived mast cells (BMMCs) were studied. The benzoxazole derivatives significantly reduced the expression of interleukin (IL)-1 beta, IL-6, IL-13, tumor necrosis factor-alpha, perilipin (PLIN) 2, and PLIN3 in BMMCs treated with LPS. Furthermore, histamine production was suppressed in BMMCs treated with LPS, or treated with phorbol-12-myristate-13-acetate/ionomycin. Benzoxazole derivatives marginally affected the surface expression of cluster of differentiation (CD)80 and CD86 on BMMCs in the presence of LPS, although LPS alone did not increase the expression of those proteins. Therefore, benzoxazole derivatives inhibited the secretion of proinflammatory cytokines in mast cells and may be potential candidate anti-allergic agents to suppress mast cell activation.
- DOI
- 10.3892/mmr.2018.8719
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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