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Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation

Title
Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation
Authors
Cho, Kyung-AhPark, MinhwaKim, Yu-HeeChoo, Hea-Young ParkLee, Kyung Ho
Ewha Authors
박혜영조경아
SCOPUS Author ID
박혜영scopus; 박혜영scopus; 조경아scopus
Issue Date
2018
Journal Title
MOLECULAR MEDICINE REPORTS
ISSN
1791-2997JCR Link

1791-3004JCR Link
Citation
MOLECULAR MEDICINE REPORTS vol. 17, no. 5, pp. 6723 - 6730
Keywords
mast cellsbenzoxazole derivatives5-lipoxygenase inhibitorshistamineinflammation
Publisher
SPANDIDOS PUBL LTD
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Mast cells are central regulators of allergic inflammation that function by releasing various proallergic inflammatory mediators, including histamine, eicosanoids and proinflammatory cytokines. Occasionally, bacterial infections may initiate or worsen allergic inflammation. A number of studies have indicated that activation of lipoxygenase in mast cells positive regulates allergic inflammatory responses by generating leukotrienes and proinflammatory cytokines. In the present study, the effects of benzoxazole derivatives on the lipopolysaccharide (LPS)-induced expression of proinflammatory cytokines, production of histamine and surface expression of co-stimulatory molecules on bone marrow-derived mast cells (BMMCs) were studied. The benzoxazole derivatives significantly reduced the expression of interleukin (IL)-1 beta, IL-6, IL-13, tumor necrosis factor-alpha, perilipin (PLIN) 2, and PLIN3 in BMMCs treated with LPS. Furthermore, histamine production was suppressed in BMMCs treated with LPS, or treated with phorbol-12-myristate-13-acetate/ionomycin. Benzoxazole derivatives marginally affected the surface expression of cluster of differentiation (CD)80 and CD86 on BMMCs in the presence of LPS, although LPS alone did not increase the expression of those proteins. Therefore, benzoxazole derivatives inhibited the secretion of proinflammatory cytokines in mast cells and may be potential candidate anti-allergic agents to suppress mast cell activation.
DOI
10.3892/mmr.2018.8719
Appears in Collections:
의과대학 > 의학과 > Journal papers
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