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Evaluation of the 1B equation to estimate glomerular filtration rate in pediatric patients with cancer

Title
Evaluation of the 1B equation to estimate glomerular filtration rate in pediatric patients with cancer
Authors
Jeong T.-D.Kim J.Lee W.Chun S.Hong K.-S.Min W.-K.
Ewha Authors
홍기숙정태동
SCOPUS Author ID
홍기숙scopus; 정태동scopus
Issue Date
2018
Journal Title
Annals of Laboratory Medicine
ISSN
2234-3806JCR Link
Citation
Annals of Laboratory Medicine vol. 38, no. 3, pp. 261 - 265
Keywords
1BBlood urea nitrogenChildrenCreatinineFull age spectrumGlomerular filtration rateUpdated Schwartz
Publisher
Seoul National University, Institute for Cognitive Science
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
The 1B equation is recommended for calculating the glomerular filtration rate (GFR) in children. Since few reports have evaluated the performance of the 1B equation, we investigated the performance of estimated GFR (eGFR) equations with the blood urea nitrogen (BUN) variable for pediatric cancer patients. In total, 203 children with cancer who underwent measured GFR (mGFR) assessment were enrolled. The median (range) mGFR and eGFR calculated using the updated Schwartz equation were 118 (43-241) and 135 (34-257) mL/min/1.73 m2, respectively. The bias, precision (root mean square error [RMSE]), and accuracy (P30, mGFR±30%) of three eGFR equations including updated Schwartz, 1B, and full age spectrum (FAS) were compared. The median bias (mL/min/1.73 m2) was: updated Schwartz, 8.5; 1B, -9.0; and FAS, 4.2. The biases for all three eGFR equations were significantly different from zero. The P30 was: updated Schwartz, 63.5%; 1B, 66.0%; and FAS, 66.0%. The RMSE was the lowest for the 1B equation (40.4), followed by FAS (42.3), and updated Schwartz (45.5). The median eGFR/mGFR ratio for the eGFR equations decreased with age and reduced kidney functions (i.e., increased creatinine and BUN concentrations). The bias may be further reduced by using the average from two equations, such as the updated Schwartz and 1B, or FAS equation, rather than using the updated Schwartz or 1B equation alone. The use of the 1B equation may underestimate the GFR. Using creatinine and BUN variables in the eGFR equation may yield a more accurate estimate of the GFR in pediatric cancer patients. © Korean Society for Laboratory Medicine.
DOI
10.3343/alm.2018.38.3.261
Appears in Collections:
의과대학 > 의학과 > Journal papers
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