Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최진호 | - |
dc.date.accessioned | 2018-11-21T16:30:31Z | - |
dc.date.available | 2018-11-21T16:30:31Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.other | OAK-22295 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/246771 | - |
dc.description.abstract | This paper presents the results of zeta potential, water contact angle, atomic force microscopy image, in vitro solubility, and content of heavy metals in polylactic acid (PLA)/chitosan (CS) nanoparticles loading nifedipine. In addition, the In Vivo test of the PLA/CS nanoparticles loading nifedipine in the mice is also one of highlights of this work. The Zeta potential result shows that the charged surface of the PLA/CS nanoparticles loading nifedipine is neutral, negative or complex depending on nifedipine content. Nifedipine plays a role in increase of hydrophobic property, swelling degree and regular surface as well as decrease of surface rough of the nanoparticles. The PLA/CS/nifedipine nanoparticles are dissolved in the solutions with pH 6.8, pH 4.5 and pH 1.2. The In Vivo test of PLA/CS nanoparticles loading nifedipine on mice was evaluated by the change in diastolic pressure, systolic pressure, arterial pressure and heart rate. The obtained results confirm that the PLA/CS nanoparticles loading nifedipine is suitable to apply in the treatment of hypertension patients lately. | - |
dc.language | English | - |
dc.title | Polylactic Acid/Chitosan Nanoparticles Loading Nifedipine: Characterization Findings and In Vivo Investigation in Animal | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 18 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2294 | - |
dc.relation.lastpage | 2303 | - |
dc.relation.journaltitle | Journal of nanoscience and nanotechnology | - |
dc.identifier.doi | 10.1166/jnn.2018.14537 | - |
dc.identifier.wosid | WOS:000426050500004 | - |
dc.identifier.scopusid | 2-s2.0-85049884552 | - |
dc.author.google | Chinh N.T. | - |
dc.author.google | Trang N.T.T. | - |
dc.author.google | Mai T.T. | - |
dc.author.google | Thanh D.T.M. | - |
dc.author.google | Trung T.H. | - |
dc.author.google | Quan L.V. | - |
dc.author.google | Hoa N.T. | - |
dc.author.google | Mao C.V. | - |
dc.author.google | Nghia N.T. | - |
dc.author.google | Hai N.T. | - |
dc.author.google | Anh T.H. | - |
dc.author.google | Hung T.V. | - |
dc.author.google | Choy J.-H. | - |
dc.author.google | Loi N.V. | - |
dc.author.google | Rajesh B. | - |
dc.author.google | Hoang T. | - |
dc.date.modifydate | 20181229081003 | - |