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Polylactic Acid/Chitosan Nanoparticles Loading Nifedipine: Characterization Findings and In Vivo Investigation in Animal
- Title
- Polylactic Acid/Chitosan Nanoparticles Loading Nifedipine: Characterization Findings and In Vivo Investigation in Animal
- Authors
- Chinh N.T.; Trang N.T.T.; Mai T.T.; Thanh D.T.M.; Trung T.H.; Quan L.V.; Hoa N.T.; Mao C.V.; Nghia N.T.; Hai N.T.; Anh T.H.; Hung T.V.; Choy J.-H.; Loi N.V.; Rajesh B.; Hoang T.
- Ewha Authors
- 최진호
- Issue Date
- 2018
- Journal Title
- Journal of nanoscience and nanotechnology
- ISSN
- 1533-4880
- Citation
- Journal of nanoscience and nanotechnology vol. 18, no. 4, pp. 2294 - 2303
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- This paper presents the results of zeta potential, water contact angle, atomic force microscopy image, in vitro solubility, and content of heavy metals in polylactic acid (PLA)/chitosan (CS) nanoparticles loading nifedipine. In addition, the In Vivo test of the PLA/CS nanoparticles loading nifedipine in the mice is also one of highlights of this work. The Zeta potential result shows that the charged surface of the PLA/CS nanoparticles loading nifedipine is neutral, negative or complex depending on nifedipine content. Nifedipine plays a role in increase of hydrophobic property, swelling degree and regular surface as well as decrease of surface rough of the nanoparticles. The PLA/CS/nifedipine nanoparticles are dissolved in the solutions with pH 6.8, pH 4.5 and pH 1.2. The In Vivo test of PLA/CS nanoparticles loading nifedipine on mice was evaluated by the change in diastolic pressure, systolic pressure, arterial pressure and heart rate. The obtained results confirm that the PLA/CS nanoparticles loading nifedipine is suitable to apply in the treatment of hypertension patients lately.
- DOI
- 10.1166/jnn.2018.14537
- Appears in Collections:
- 연구기관 > 의과학연구소 > Journal papers
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