Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2018-11-21T16:30:13Z | - |
dc.date.available | 2018-11-21T16:30:13Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1226-8453 | * |
dc.identifier.issn | 2093-4947 | * |
dc.identifier.other | OAK-23337 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/246675 | - |
dc.description.abstract | Background: The potential therapeutic values of Korean Red Ginseng extract (KRGE) in autoimmune disorders of nervous system have not been fully investigated. Methods: We used an acute experimental autoimmune encephalomyelitis animal model of multiple sclerosis and determined the effects and mechanism of KRGE on spinal myelination. Results: Pretreatment with KRGE (100 mg/kg, orally) for 10 days before immunization with myelin basic protein (MBP)(68-82) peptide exerted a protective effect against demyelination in the spinal cord, with inhibited recruitment and activation of immune cells including microglia, decreased mRNA expression of detrimental inflammatory mediators (interleukin-6, interferon-gamma, and cyclooxygenase-2), but increased mRNA expression of protective inflammatory mediators (insulin-like growth factor beta 1, transforming growth factor beta, and vascular endothelial growth factor-1). These results were associated with significant downregulation of p38 mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways in microglia/macrophages, T cells, and astrocytes. Conclusion: Our findings suggest that KRGE alleviates spinal demyelination in acute experimental autoimmune encephalomyelitis through inhibiting the activation of the p38 mitogen-activated protein kinase/nuclear factor-kappa B signaling pathway. Therefore, KRGE might be used as a new therapeutic for autoimmune disorders such as multiple sclerosis, although further investigation is needed. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC GINSENG | * |
dc.subject | demyelination | * |
dc.subject | experimental autoimmune encephalomyelitis | * |
dc.subject | Korean Red Ginseng | * |
dc.subject | nuclear factor-kappa B | * |
dc.subject | p-38 mitogen-activated protein kinase | * |
dc.title | Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 42 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 436 | * |
dc.relation.lastpage | 446 | * |
dc.relation.journaltitle | JOURNAL OF GINSENG RESEARCH | * |
dc.identifier.doi | 10.1016/j.jgr.2017.04.013 | * |
dc.identifier.wosid | WOS:000447034200005 | * |
dc.identifier.scopusid | 2-s2.0-85020476164 | * |
dc.author.google | Lee, Min Jung | * |
dc.author.google | Chang, Byung Joon | * |
dc.author.google | Oh, Seikwan | * |
dc.author.google | Nah, Seung-Yeol | * |
dc.author.google | Cho, Ik-Hyun | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |