View : 584 Download: 0
Is Clostridium difficile infection a real threat in patients with ulcerative colitis? A prospective, multicenter study in Korea
- Title
- Is Clostridium difficile infection a real threat in patients with ulcerative colitis? A prospective, multicenter study in Korea
- Authors
- Kim D.B.; Lee K.-M.; Park S.H.; Kim Y.S.; Kim E.S.; Lee J.; Jung S.-A.; Seo G.S.; Lee J.M.
- Ewha Authors
- 정성애
- SCOPUS Author ID
- 정성애
- Issue Date
- 2018
- Journal Title
- Intestinal Research
- ISSN
- 1598-9100
- Citation
- Intestinal Research vol. 16, no. 2, pp. 267 - 272
- Keywords
- Clostridium infections; Colitis, ulcerative; Polymerase chain reaction; Prevalence
- Publisher
- Korean Association for the Study of Intestinal Diseases
- Indexed
- SCOPUS; KCI
- Document Type
- Article
- Abstract
- Background/Aims: Clostridium difficile infection (CDI) has been reported to be a cause of flare-ups in patients with ulcerative colitis (UC). We evaluated the prevalence and clinical outcomes of CDI in patients with UC hospitalized for flare-ups. Methods: This was a prospective, multicenter study including 7 academic teaching hospitals in Korea. All consecutive patients with UC admitted for disease flare-up were enrolled. We detected the presence of CDI by using enzyme immunoassay, real-time polymerase chain reaction (RT-PCR) for toxin genes, and sigmoidoscopy. Results: Eighty-one consecutive patients with UC were enrolled from January 2014 to December 2015. Among 81 patients, 8 (9.9%) were diagnosed with CDI. Most of the cases were identified by RT-PCR. Enzyme immunoassay was positive in 3 of 8 patients, and only 1 had typical endoscopic findings of pseudomembranous colitis. There were no differences in demographic data, length of hospital stay, or colectomy rate between patients with and without CDI. Conclusions: CDI was not a rare cause of flare-up in patients with UC in Korea. However, CDI did not appear to affect the course of UC flare-up in Korean patients. RT-PCR was sensitive in detecting CDI and can be considered a diagnostic tool in patients with UC flare-up. ©2018. Korean Association for the Study of Intestinal Diseases.
- DOI
- 10.5217/ir.2018.16.2.267
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML