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The effect of polydeoxyribonucleotide on chronic non-healing wound of an amputee: A case report

Title
The effect of polydeoxyribonucleotide on chronic non-healing wound of an amputee: A case report
Authors
Shin J.Park G.Lee J.Bae H.
Ewha Authors
배하석
SCOPUS Author ID
배하석scopus
Issue Date
2018
Journal Title
Annals of Rehabilitation Medicine
ISSN
2234-0645JCR Link
Citation
Annals of Rehabilitation Medicine vol. 42, no. 4, pp. 630 - 633
Keywords
AmputeesPolydeoxyribonucleotidesWound healing
Publisher
Korean Academy of Rehabilitation Medicine
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refractory to negative pressure wound therapy, skin graft, or growth factors. Three injections of PDRN were administered at the wound site into the anterior and medial sides of the left stump on the 1st, 4th, and 9th days of hospitalization. The PDRN ameliorated wound healing by enhancing cell growth, tissue repair, and angiogenesis. PDRN application represents a potential treatment for non-healing wounds obviating the need for additional therapies, and hospitalization, as well as improve patient's activities of daily living. © 2018 by Korean Academy of Rehabilitation Medicine.
DOI
10.5535/arm.2018.42.4.630
Appears in Collections:
의과대학 > 의학과 > Journal papers
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