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Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor delta Agonist
- Title
- Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor delta Agonist
- Authors
- Lee, Su-Jeong; Samala, Mallesham; Woo, Seo Yeon; Hahn, Dongyup; Kim, Dayoung; Kadayat, Tara Man; Jung, Kyungjin; Kim, Jina; Kim, Dong-Su; Kwon, Sugyeong; Kim, Shinae; Kim, Kyung-Hee; Nam, Sang-Jip; Cho, Sung Jin; Chin, Jungwook
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2018
- Journal Title
- ACS OMEGA
- ISSN
- 2470-1343
- Citation
- ACS OMEGA vol. 3, no. 2, pp. 1970 - 1976
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of L-threonine.
- DOI
- 10.1021/acsomega.7b01689
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
- Files in This Item:
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Enantioselective Synthesis.pdf(744.77 kB)
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