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Syndecan transmembrane domain modulates intracellular signaling by regulating the oligomeric status of the cytoplasmic domain

Title
Syndecan transmembrane domain modulates intracellular signaling by regulating the oligomeric status of the cytoplasmic domain
Authors
Jang B.Jung H.Hong H.Oh E.-S.
Ewha Authors
오억수
SCOPUS Author ID
오억수scopus
Issue Date
2018
Journal Title
Cellular Signalling
ISSN
0898-6568JCR Link
Citation
vol. 52, pp. 121 - 126
Keywords
DimerizationReceptorSignal transductionSyndecanTransmembrane domain
Publisher
Elsevier Inc.
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
Cell surface receptors must specifically recognize an extracellular ligand and then trigger an appropriate response within the cell. Their general structure enables this, as it comprises an extracellular domain that can bind an extracellular ligand, a cytoplasmic domain that can transduce a signal inside the cell to produce an appropriate response, and a transmembrane domain that links the two and is responsible for accurately delivering specific information on a binding event from the extracellular domain to the cytoplasmic domain, to trigger the proper response. A vast body of research has focused on elucidating the specific mechanisms responsible for regulating extracellular binding events and the subsequent interactions of the cytoplasmic domain with intracellular signaling. In contrast, far less work has focused on examining how the transmembrane domain links these domains and delivers the necessary information. In this review, we propose the importance of the transmembrane domain as a signal regulator. We highlight the cell adhesion receptor, syndecan, as a special case, and propose that the transmembrane domain-mediated oligomerization of the syndecan cytoplasmic domain is a unique regulatory mechanism in syndecan signaling. © 2018
DOI
10.1016/j.cellsig.2018.09.003
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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