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Clinical value of delayed 18F-FDG PET/CT for predicting nipple-areolar complex involvement in breast cancer: A comparison with clinical symptoms and breast MRI

Title
Clinical value of delayed 18F-FDG PET/CT for predicting nipple-areolar complex involvement in breast cancer: A comparison with clinical symptoms and breast MRI
Authors
Yoo J.Kim B.S.Chung J.Yoon H.-J.
Ewha Authors
김범산정진윤혜전
SCOPUS Author ID
김범산scopus; 정진scopus; 윤혜전scopus
Issue Date
2018
Journal Title
PLoS ONE
ISSN
1932-6203JCR Link
Citation
vol. 13, no. 9
Publisher
Public Library of Science
Indexed
SCIE; SCOPUS scopus
Abstract
Objective We aimed to evaluate the predictive value of delayed 18F-FDG PET/CT for identifying malignancies involved in the nipple-areolar complex (NAC) in comparison with clinical symptoms and breast MRI. Methods We enrolled 90 patients who underwent preoperative delayed 18F-FDG PET/CT and MRI between October 2015 and May 2017. We calculated the NAC-Standardized uptake value ratio (SUVR) using the following formula: maximum SUV (SUVmax) of the NAC in the malignant breast /SUVmax of the NAC in the contralateral normal breast on early (NAC-SUVRearly) and delayed (NAC-SUVRdelay) phase images. MRI was used to measure the distance between the tumor and NAC and to analyze NAC enhancement patterns. Univariate and multivariate analyses were performed to identify significant predictive factors for NAC involvement. Results Seventeen patients were confirmed to have pathologic NAC involvement. NAC symptoms (p = 0.009), tumor multiplicity (p = 0.006), NAC-SUVRdelay (> 1.23, p = 0.007), and MRI-based tumor-to-NAC distance ( 22.0 mm, p = 0.003) were independent predictive factors for NAC involvement. Ten of 76 patients with no clinical NAC symptoms had NAC malignancy. Tumor multiplicity (p = 0.009), tumor-to-NAC distance ( 20.0 mm, p = 0.014)), and NAC-SUVRdelay (> 1.23, p = 0.018) had independent predictive value for NAC involvement. Conclusions Delayed 18F-FDG PET/CT is a useful modality for predicting NAC involvement in breast cancer patients whether or not NAC symptoms are present. © 2018 Yoo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI
10.1371/journal.pone.0203649
Appears in Collections:
의과대학 > 의학과 > Journal papers
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