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Abrogation of the Circadian Nuclear Receptor REV-ERB alpha Exacerbates 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration

Title
Abrogation of the Circadian Nuclear Receptor REV-ERB alpha Exacerbates 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration
Authors
Kim, JeongahJang, SangwonChoi, MijungChung, SooyoungChoe, YoungshikChoe, Han KyoungSon, Gi HoonRhee, KunsooKim, Kyungjin
Ewha Authors
정수영
SCOPUS Author ID
정수영scopus
Issue Date
2018
Journal Title
MOLECULES AND CELLS
ISSN
1016-8478JCR Link0219-1032JCR Link
Citation
vol. 41, no. 8, pp. 742 - 752
Keywords
6-hydroxydoapmineneurodegenerationcircadian clockParkinson's diseaseREV-ERB alpha
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Indexed
SCI; SCIE; SCOPUS; KCI WOS
Abstract
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of dopaminergic (DAergic) neurons, particularly in the substantia nigra (SN). Although circadian dysfunction has been suggested as one of the pathophysiological risk factors for PD, the exact molecular link between the circadian clock and PD remains largely unclear. We have recently demonstrated that REV-ERB alpha, a circadian nuclear receptor, serves as a key molecular link between the circadian and DAergic systems. It competitively cooperates with NURR1, another nuclear receptor required for the optimal development and function of DA neurons, to control DAergic gene transcription. Considering our previous findings, we hypothesize that REV-ERB alpha may have a role in the onset and/or progression of PD. In the present study, we therefore aimed to elucidate whether genetic abrogation of REV-ERB alpha affects PD-related phenotypes in a mouse model of PD produced by a unilateral injection of 6-hydroxydopamine (6-OHDA) into the dorsal striatum. REV-ERB alpha deficiency significantly exacerbated 6-OHDA-induced motor deficits as well as DAergic neuronal loss in the vertebral midbrain including the SN and the ventral tegmental area. The exacerbated DAergic degeneration likely involves neuroinflammation-mediated neurotoxicity. The Rev-erb alpha knockout mice showed prolonged microglial activation in the SN along with the overproduction of interleukin 1 beta, a pro-inflammatory cytokine, in response to 6-OHDA. In conclusion, the present study demonstrates for the first time that genetic abrogation of REV-ERB alpha can increase vulnerability of DAergic neurons to neurotoxic insults, such as 6-OHDA, thereby implying that its normal function may be beneficial for maintaining DAergic neuron populations during PD progression.
DOI
10.14348/molcells.2018.0201
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스크랜튼대학 > 융합학부 > Journal papers
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