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Association of blood pressure components with mortality and cardiovascular events in prehypertensive individuals: a nationwide population-based cohort study

Title
Association of blood pressure components with mortality and cardiovascular events in prehypertensive individuals: a nationwide population-based cohort study
Authors
Oh, Hyung JungLee, SeulbiLee, Eun-KyungLee, OesookHa, EunheePark, Eun-MiKim, Seung-JungKang, Duk-HeeChoi, Kyu BokKim, Seung JunRyu, Dong-Ryeol
Ewha Authors
이외숙하은희강덕희최규복김승정박은미류동열이은경
SCOPUS Author ID
이외숙scopus; 하은희scopus; 강덕희scopus; 최규복scopus; 김승정scopus; 박은미scopus; 류동열scopus; 이은경scopus
Issue Date
2018
Journal Title
ANNALS OF MEDICINE
ISSN
0785-3890JCR Link1365-2060JCR Link
Citation
vol. 50, no. 5, pp. 443 - 452
Keywords
Blood pressure componentsall-cause mortalitycardiovascular eventsprehypertension
Publisher
TAYLOR & FRANCIS LTD
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Background: The effects of each blood pressure index [systolic and diastolic blood pressure (SBP, DBP), pulse pressure (PP), mean arterial pressure (MAP)] on the occurrence of mortality and cardiovascular (CV) events have not yet been investigated in prehypertensive populations.Methods: A total of 30,258 prehypertensive Korean participants underwent periodic health examination between 2003 and 2004 were enrolled, and the associations of BP components with mortality and CV events were investigated. Moreover, based on the DBP [80 DBP <90mmHg (N=21,323) and DBP <80mmHg (N=8,935)], the effects of BP components were also evaluated.Results: Multivariate Cox analyses in prehypertensive group revealed that the hazard ratios (HRs) were 1.121 and 1.130 per 10mmHg increase in SBP and PP for mortality, respectively. Additionally, 10mmHg increase of SBP (HR:1.090) was still significantly, but increase of PP (HR:1.060) was marginally associated with higher incidence of CV events. However, there were no significant associations with increase in DBP or MAP on adverse clinical outcomes in prehypertensive group. In the prehypertensive subjects with DBP <80mmHg, CV events more frequently occurred by 38.8% and 28.5% per 10mmHg increase in SBP and PP, respectively.Conclusions: Prehypertensive subjects might need to be cautioned when they have high SBP or PP with low DBP even in healthy populations.Key messagePrehypertensive subjects should be cautioned when they have high-systolic blood pressure or pulse pressure with low-diastolic blood pressure, even without previous hypertension, diabetes mellitus or chronic kidney disease.
DOI
10.1080/07853890.2018.1492146
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자연과학대학 > 통계학전공 > Journal papers
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