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Recent progress on the development of glutathione (GSH) selective fluorescent and colorimetric probes

Title
Recent progress on the development of glutathione (GSH) selective fluorescent and colorimetric probes
Authors
Lee, SongyiLi, JunZhou, XinYin, JunYoon, Juyoung
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2018
Journal Title
COORDINATION CHEMISTRY REVIEWS
ISSN
0010-8545JCR Link1873-3840JCR Link
Citation
vol. 366, pp. 29 - 68
Keywords
Fluorescence probesGSH probesColorimetric chemosensorsBiothiol probesGlutathione probeBioimaging
Publisher
ELSEVIER SCIENCE SA
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Glutathione (GSH) plays a key role in many cellular functions. Abnormal levels of GSH is considered to be sign of many diseases. As a result, various fluorescent imaging probes and/or chemosensors for GSH have been developed. Compared to other analytical methods, fluorescence has unique merits, such as excellent detection limits and sensitivity for use in imaging cells, tissues and small animals. However, colorimetric probes undergo distinct color changes, which in most cases can be detected by using the naked eye. This review of studies aimed at the development of GSH probes is presented in a format that is organized by structural features and chemical reactions of the probes. The topics include probes that are based on nanoparticles or nanocomposites, metal ion displacement and coordination and chemical reactions. The reaction based probes are further classified into probes that undergo cleavage of sulphonamide, sulfonate ester and related functional groups, Se-N bond cleavage, aryl substitution reactions, disulfide bond cleavage followed by cyclization, Michael additions, and other processes. (C) 2018 Elsevier B.V. All rights reserved.
DOI
10.1016/j.ccr.2018.03.021
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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