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Feasibility of myocardial PET imaging using a benzylguanidine analog: meta-(3-[F-18]fluoropropyl)benzylguanidine ([F-18]mFPBG)

Title
Feasibility of myocardial PET imaging using a benzylguanidine analog: meta-(3-[F-18]fluoropropyl)benzylguanidine ([F-18]mFPBG)
Authors
Woo, Sang-KeunMoon, Byung SeokKim, Bom SahnKim, Min HwanLee, Yong JinJung, Jae HoLee, Kyo ChulSeo, YounghoKim, WookLim, Sang MooLee, Byung ChulKim, Sang Eun
Ewha Authors
김범산
SCOPUS Author ID
김범산scopus
Issue Date
2018
Journal Title
NUCLEAR MEDICINE AND BIOLOGY
ISSN
0969-8051JCR Link1872-9614JCR Link
Citation
vol. 61, pp. 63 - 70
Keywords
Cardiac sympathetic innervationF-18PETGuanidineMyocardial infarction
Publisher
ELSEVIER SCIENCE INC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Introduction: Global and regional sympathetic activity in the heart can be evaluated using [I-123]meta-iodobenzylguanidine ([I-123]mIBG) imaging. However, [I-123]mIBG is associated with low image spatial resolution and sensitivity in cardiac imaging. We investigated the capability of an F-18-labeled mIBG derivative, meta-(3-[F-18]fluoropropyl)benzylguanidine ([F-18]mFPBG), for identifying ischemic and viable myocardium in a rat model of myocardial infarction. Materials and Methods: The ex vivo biodistribution and in vivo metabolic stability of [F-18]mFPBG were investigated in Sprague-Dawley rats. Selective cardiac adrenergic activation was confirmed via a blocking experiment involving pretreatment with desipramine (2 mg kg(-1)), followed by the administration of [F-18]mFPBG. Imaging properties of [F-18]mFPBG were compared with those of traditional cardiac imaging radiotracers ([I-123]mIBG and [Tc-99m]MIBI) in a rat model of myocardial infarction. Non-invasive image-based measurements of infarct sizes were then compared with histological findings by using Bland-Altman analysis. Results: The differences in infarct sizes determined using histological analysis and [F-18]mFPBG PET were -2.55 +/- 4.99% (range: -12.33 to 7.22), -2.35 +/- 3.32% (range: -8.87 to 4.16), and -3.15 +/- 6.16% (range: -15.24 to 8.93) at 5, 20, and 40 min, respectively. Furthermore, [F-18]mFPBG PET was superior to traditional imaging methods in assessing the degree of ischemia in areas of myocardial infarction, as well as the actual infarct size. Conclusion: Compared to [I-123]mIBG, [F-18]mFPBG showed improved spatial resolution and sensitivity in a rat model of myocardial infarction. This result suggested that [F-18]mFPBG is a promising cardiac PET imaging agent for potential diagnostic application in PET cardiology. (C) 2018 Elsevier Inc. All rights reserved.
DOI
10.1016/j.nucmedbio.2018.04.005
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의과대학 > 의학과 > Journal papers
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