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Oncologic outcome of colorectal cancer patients over age 80: a propensity score-matched analysis

Title
Oncologic outcome of colorectal cancer patients over age 80: a propensity score-matched analysis
Authors
Oh, Bo YoungHuh, Jung WookKim, Hee CheolPark, Yoon AhCho, Yong BeomYun, Seong HyeonLee, Woo YongChun, Ho-Kyung
Ewha Authors
오보영
Issue Date
2018
Journal Title
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
ISSN
0179-1958JCR Link1432-1262JCR Link
Citation
vol. 33, no. 8, pp. 1011 - 1018
Keywords
ChemotherapyColorectal cancerOld ageSurgerySurvival
Publisher
SPRINGER
Indexed
SCIE; SCOPUS WOS scopus
Abstract
It remains unclear whether old age is a poor prognostic factor in colorectal cancer (CRC). We compared oncologic outcomes in CRC patients according to age, using 80 as the dividing point. CRC patients who underwent radical surgery from 2000 to 2011 were evaluated. We performed matched and adjusted analyses comparing oncologic outcomes between patients with >= 80 and < 80 years old. Among 9562 patients, 222 were elderly. The median age was 82.0 years in elderly patients and 59.0 years in young patients. Elderly patients received less neoadjuvant or adjuvant therapy compared to young patients (p < 0.001). After recurrence, significantly fewer elderly patients received additional treatments (p < 0.001). Before matching, disease-free survival (DFS) and cancer-specific survival (CSS) were significantly lower for elderly patients compared to those for young patients (p < 0.001 and p < 0.001, respectively). After matching, DFS and CCS were not significantly different between the two groups (p = 0.400 and p = 0.267, respectively). In a multivariate analysis for prognostic factors, old age was not an independent poor prognostic factor of DFS and CCS (p = 0.619 and p = 0.137, respectively). Elderly patients aged >= 80 years with CRC had similar oncologic outcome to young patients, and age was not an independent prognostic factor.
DOI
10.1007/s00384-018-3028-4
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의료원 > 의료원 > Journal papers
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