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A double blind, placebo-controlled, randomized clinical trial that breast milk derived Lactobacillus gasseri BNR17 mitigated diarrhea-dominant irritable bowel syndrome

Title
A double blind, placebo-controlled, randomized clinical trial that breast milk derived Lactobacillus gasseri BNR17 mitigated diarrhea-dominant irritable bowel syndrome
Authors
Shin, Suk PyoChoi, Yoon MiKim, Won HeeHong, Sung PyoPark, Jong-MinKim, JooheeKwon, OranLee, Eun HyunHahm, Ki Baik
Ewha Authors
권오란김주희
SCOPUS Author ID
권오란scopus; 김주희scopusscopus
Issue Date
2018
Journal Title
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
ISSN
0912-0009JCR Link1880-5086JCR Link
Citation
vol. 62, no. 2, pp. 179 - 186
Keywords
diarrhea-dominant IBSLactobacillus gasseri BNR17IBS-QOLcolon transit timemicrobiota
Publisher
JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The exact pathogenesis of diarrhea-dominant irritable bowel syndrome (IBS) is not known, but the abnormal microbiota of the gastrointestinal tract is considered to be one of the important contributing factors as in other gastrointestinal diseases such as inflammatory bowel disease, antibiotic-associated diarrhea, and colorectal cancer as well as systemic diseases. Though diverse trials of probiotics had been continued in the treatment of diarrhea-IBS, only a few proved by randomized clinical trial. To prove the efficacy of Lactobacillus gasseri BNR17 isolated from breast milk in patients with diarrhea-IBS, prospective, randomized, placebo controlled clinical trial was done including health related-quality of life analysis, colon transit time, and the changes of fecal micro-biota. BNR17 significantly improved the symptoms of diarrhea compared to control group. Health related-QOL analysis showed significant improvement of abdominal pain, distension, disturbed daily life, and mean defecation frequency with BNR17. On comparative CTT before and after BNR17, 6 out of 24 subjects showed significant correction of rapid colon transit pattern, while only 2 out of 24 in placebo (p < 0.01). Upon fecal microbiota analysis, BNR17 significantly increased B. fecalis, E. rectale, C. aerofaciens, F. prausnitzil and B. steroris. Conclusively, Lactobacillus gasseri BNR17 can be a potential probiotics to ameliorate diarrhea-IBS.
DOI
10.3164/jcbn.17-73
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신산업융합대학 > 식품영양학과 > Journal papers
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