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Assessment of Quality of Life and Safety in Postmenopausal Breast Cancer Patients Receiving Letrozole as an Early Adjuvant Treatment
- Assessment of Quality of Life and Safety in Postmenopausal Breast Cancer Patients Receiving Letrozole as an Early Adjuvant Treatment
- Cho, Young Up; Gwak, Geum Hee; Park, Yong Lae; Kim, Sang Wook; Han, Sehwan; Cho, Se Hun; Kim, Lee Su; Moon, Byung In; Jung, Sung Hoo; Lim, Chol Wan; Kim, Sung Yong; Park, Ho Yong; Song, Jeongyoon; Lee, Kwang Man; Park, Sung Hwan; Jeong, Joon; Park, Hae Lin; Kim, Sung Won; Kwak, Beom Seok; Kang, Sun Hee; Jung, Yongsik; Lee, Soo Jung; Lee, Juneyoung; Noh, Woo Chul; Nam, Seok Jin; Park, Byeong-Woo; Bae, Young Tae; Kang, Sung-Soo; Parks, Heung Kyu; Yoon, Jung-Han; Kim, Je Ryong
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- JOURNAL OF BREAST CANCER
- 1738-6756; 2092-9900
- vol. 21, no. 2, pp. 182 - 189
- Breast neoplasms; Letrozole; Quality of life; Treatment
- KOREAN BREAST CANCER SOC
- SCIE; SCOPUS; KCI
- Purpose: There are few reports from Asian countries about the long-term results of aromatase inhibitor adjuvant treatment for breast cancer. This observational study aimed to evaluate the long-term effects of letrozole in postmenopausal Korean women with operable breast cancer. Methods: Self-reported quality of life (QoL) scores were serially assessed for 3 years during adjuvant letrozole treatment using the Korean version of the Functional Assessment of Cancer Therapy-Breast questionnaires (version 3). Changes in bone mineral density (BMD) and serum cholesterol levels were also examined. Results: All 897 patients received the documented informed consent form and completed a baseline questionnaire before treatment. Adjuvant chemotherapy was administered to 684 (76.3%) subjects, and 410 (45.7%) and 396 (44.1%) patients had stage I and II breast cancer, respectively. Each patient completed questionnaires at 3, 6, 12, 18, 24, 30, and 36 months after enrollment. Of 897 patients, 749 (83.5%) completed the study. The dropout rate was 16.5%. The serial trial outcome index, the sum of the physical and functional well-being subscales, increased gradually and significantly from baseline during letrozole treatment (p<0.001). The mean serum cholesterol level increased significantly from 199 to 205 after 36 months (p = 0.042). The mean BMD significantly decreased from -0.39 at baseline to -0.87 after 36 months (p<0.001). Conclusion: QoL gradually improved during letrozole treatment. BMD and serum cholesterol level changes were similar to those in Western countries, indicating that adjuvant letrozole treatment is well tolerated in Korean women, with minimal ethnic variation.
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