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Optic nerve sheath diameter measured using early unenhanced brain computed tomography shows no correlation with neurological outcomes in patients undergoing targeted temperature management after cardiac arrest

Title
Optic nerve sheath diameter measured using early unenhanced brain computed tomography shows no correlation with neurological outcomes in patients undergoing targeted temperature management after cardiac arrest
Authors
Lee, Dong HoonLee, Sun HwaOh, Je HyeokCho, In SooLee, Young HwanHan, ChulChoi, Wook JinSohn, You DongKORHN Investigators
Ewha Authors
한철
SCOPUS Author ID
한철scopus
Issue Date
2018
Journal Title
RESUSCITATION
ISSN
0300-9572JCR Link
Citation
vol. 128, pp. 144 - 150
Keywords
Optic nerve sheath diameterCardiac arrestNeurological outcomeTargeted temperature managementPost-cardiac arrest syndromePrognostic factor
Publisher
ELSEVIER IRELAND LTD
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Aim: Previous studies indicated that the optic nerve sheath diameter (ONSD) measured using brain computed tomography (CT) is a prognostic factor for poor neurological outcome after cardiac arrest. However, these studies were retrospective or included a small sample size. We performed a prospective multi-centre observational study to investigate the correlation between the ONSD on early brain CT and neurological outcomes in patients undergoing targeted temperature management (TTM). Methods: This study used data from the Korean Hypothermia Network prospective registry between November 2015 and October 2016. Out-of-cardiac arrest patients who underwent brain CT within 2 h after return of spontaneous circulation (ROSC) were included. The primary endpoint was neurological outcomes at 6 months (cerebral performance category; CPC); the secondary outcome was hospital mortality. The ONSD was measured using unenhanced brain CT images. Results: In total, 374 patients were included from 18 hospitals, and 329 underwent CT within 2 h after ROSC. Six months after cardiac arrest, good (CPC 1-2) and poor (CPC 3-5) neurological outcomes were observed in 99 (30.09%) and 230 (69.91%) patients, respectively. There was no significant difference in the ONSD between groups (good outcome group: 5.61 +/- 0.59 mm, poor outcome group: 5.69 +/- 0.79 mm; p = 0.275), nor between discharged patients who survived and those with hospital mortality (5.63 +/- 0.64 mm and 5.70 +/- 0.67 mm, respectively, p = 0.399). Conclusion: The ONSD on initial brain CT after ROSC was not correlated with neurological outcome at 6 months in patients who underwent TTM.
DOI
10.1016/j.resuscitation.2018.04.041
Appears in Collections:
의과대학 > 의학과 > Journal papers
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