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Sleep-Aids Derived from Natural Products

Title
Sleep-Aids Derived from Natural Products
Authors
Hu, ZhenzhenOh, SeikwanHa, Tae-WooHong, Jin-TaeOh, Ki-Wan
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2018
Journal Title
BIOMOLECULES & THERAPEUTICS
ISSN
1976-9148JCR Link2005-4483JCR Link
Citation
vol. 26, no. 4, pp. 343 - 349
Keywords
InsomniaSleepNatural productsPharmacological mechanismsElectroencephalography (EEG)
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Although drugs such as barbiturates and benzodiazepines are often used for the treatment of insomnia, they are associated with various side effects such as habituations, tolerance and addiction. Alternatively, natural products with minimal unwanted effects have been preferred for the treatment of acute and/or mild insomnia, with additional benefits of overall health-promotion. Basic and clinical researches on the mechanisms of action of natural products have been carried out so far in insomnia treatments. Recent studies have been focusing on diverse chemical components available in natural products, with an interest of developing drugs that can improve sleep duration and quality. In the last 15 years, our co-workers have been actively looking for candidate substances from natural products that can relieve insomnia. This review is, therefore, intended to bring pharmacological data regarding to the effects of natural products on sleep duration and quality, mainly through the activation of GABAA receptors. It is imperative that phytochemicals will provide useful information during electroencephalography (EEG) analysis and serve as an alternative medications for insomnia patients who are reluctant to use conventional drugs.
DOI
10.4062/biomolther.2018.099
Appears in Collections:
의과대학 > 의학과 > Journal papers
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