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Synthesis, antimicrobial activities and cytogenetic studies of newer diazepino quinoline derivatives via Vilsmeier-Haack reaction

Title
Synthesis, antimicrobial activities and cytogenetic studies of newer diazepino quinoline derivatives via Vilsmeier-Haack reaction
Authors
Nandhakumar R.Suresh T.Jude A.L.C.Rajesh kannan V.Mohan P.S.
Ewha Authors
Raju Nandhakumar
Issue Date
2007
Journal Title
European Journal of Medicinal Chemistry
ISSN
0223-5234JCR Link
Citation
vol. 42, no. 8, pp. 1128 - 1136
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The study of the Vilsmeier-Haack reagent on 4-hydroxyquinaldines resulted in a new versatile intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-1-yl)quinolines, which on further treatment with hydrazine hydrate yielded the desired diazepino quinoline derivatives. All the synthesized diazepino quinoline derivatives are screened for their antibacterial and antifungal activities. Cytogenetic analysis of the samples is also reported. © 2007 Elsevier Masson SAS. All rights reserved.
DOI
10.1016/j.ejmech.2007.01.004
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연구기관 > 나노·바이오기술연구소 > Journal papers
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