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Effect of SKI 306X, a New herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study

Title
Effect of SKI 306X, a New herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study
Authors
Jung Y.B.Roh K.-J.Jung J.-A.Jung K.Yoo H.Cho Y.-B.Kwak W.-J.Kim D.-K.Kirn K.H.Han C.-K.
Ewha Authors
노권재김대기
SCOPUS Author ID
노권재scopus; 김대기scopus
Issue Date
2001
Journal Title
American Journal of Chinese Medicine
ISSN
0192-415XJCR Link
Citation
vol. 29, no. 3-4, pp. 485 - 491
Indexed
SCIE; SCOPUS scopus
Abstract
SKI 306X is a purified extract from a mixture of three oriental herbal medicines (Clematis mandshurica, Trichosanthes kirilowii and Pnmella vtilgaris) that have been widely used for the treatment of inflammatory diseases such as lymphadenitis and arthritis in far East Asia. A double-blind, controlled study was performed to evaluate the efficacy and safety of SKI 306X with placebo in 96 patients with classical osteoarthritis of the knee. Patients were randomized to four treatment groups: placebo, 200 mg, 400 mg and 600 mg of SKI 306X t.i.d.. Clinical efficacy and safety were evaluated for4 weeks continuous treatment. SKI 306X demonstrated its clinical efficacy, as assessed by 100 mm visual analogue scale (VAS), Lequesne index and patients' and investigators opinion of the therapeutic effect compared with placebo (p<0.01). No significant adverse events were observed in patients treated with SKI 306X. This study demonstrated that SKI 306X, a new herbal anti-arthritic agent provided clinical efficacy in patients with osteoarthritis. © 2001 Institute for Advanced Research in Asian Science and Medicine.
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의과대학 > 의학과 > Journal papers
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