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Comparison of midazolam versus midazolam/meperidine during colonoscopy in a prospective, randomized, double-blind study

Title
Comparison of midazolam versus midazolam/meperidine during colonoscopy in a prospective, randomized, double-blind study
Authors
Jung H.K.Bae K.S.Yoon S.J.Lee J.S.Kwon J.M.Yoo M.A.
Ewha Authors
정혜경
SCOPUS Author ID
정혜경scopus
Issue Date
2004
Journal Title
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
ISSN
1598-9992JCR Link
Citation
vol. 43, no. 2, pp. 96 - 103
Indexed
SCOPUS; KCI scopus
Abstract
BACKGROUND/AIMS: Colonoscopy is a painful procedure. Therefore conscious sedation is often used. However, the value of adding analgesics to sedatives has not been well evaluated. METHODS: The double blind, randomized controlled trial was carried out to compare patients' and endoscopist' assessments in both groups of patients: MP (Midazolam/Placebo) group (n=49) received midazolam plus placebo and MM (Midazolam/Meperidine) group (n=51) received midazolam plus meperidine. RESULTS: There was no significant difference of baseline characteristics except previous operation history. There were no significant difference of grade of tolerance, pain and willingness to another colonoscopy between the two groups. In endoscopist' satisfaction, the degree of difficulty was higher in MP group than in MM group (39.0 vs. 31.7,p<0.05). After the colonoscopy, systolic blood pressure, oxygen saturation, and pulse rate were significantly decreased (p<0.05) in both groups. However, there was no difference in the degree of decrease between the two groups. The incidence of adverse effect was not different in the two groups. However, one case of orthostatic hypotension with presyncope was noted in MM group. CONCLUSIONS: Adding meperidine to the midazolam before the colonoscopy does not seem to bring more beneficial effect to patients, whereas endoscopist favored the use of both medications.
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의과대학 > 의학과 > Journal papers
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