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Redox-based regulation of signal transduction: Principles, pitfalls, and promises

Title
Redox-based regulation of signal transduction: Principles, pitfalls, and promises
Authors
Janssen-Heininger Y.M.W.Mossman B.T.Heintz N.H.Forman H.J.Kalyanaraman B.Finkel T.Stamler J.S.Rhee S.G.van der Vliet A.
Ewha Authors
이서구
SCOPUS Author ID
이서구scopusscopus
Issue Date
2008
Journal Title
Free Radical Biology and Medicine
ISSN
0891-5849JCR Link
Citation
vol. 45, no. 1, pp. 1 - 17
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Oxidants are produced as a by-product of aerobic metabolism, and organisms ranging from prokaryotes to mammals have evolved with an elaborate and redundant complement of antioxidant defenses to confer protection against oxidative insults. Compelling data now exist demonstrating that oxidants are used in physiological settings as signaling molecules with important regulatory functions controlling cell division, migration, contraction, and mediator production. These physiological functions are carried out in an exquisitely regulated and compartmentalized manner by mild oxidants, through subtle oxidative events that involve targeted amino acids in proteins. The precise understanding of the physiological relevance of redox signal transduction has been hampered by the lack of specificity of reagents and the need for chemical derivatization to visualize reversible oxidations. In addition, it is difficult to measure these subtle oxidation events in vivo. This article reviews some of the recent findings that illuminate the significance of redox signaling and exciting future perspectives. We also attempt to highlight some of the current pitfalls and the approaches needed to advance this important area of biochemical and biomedical research. © 2008 Elsevier Inc.
DOI
10.1016/j.freeradbiomed.2008.03.011
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일반대학원 > 생명·약학부 > Journal papers
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