View : 47 Download: 0

A report on the diagnosis of intermediate hyperglycemia in Korea: A pooled analysis of four community-based cohort studies

Title
A report on the diagnosis of intermediate hyperglycemia in Korea: A pooled analysis of four community-based cohort studies
Authors
Oh J.-Y.Lim S.Kim D.J.Kim N.H.Moon S.D.Jang H.C.Cho Y.M.Song K.-H.Ahn C.W.Sung Y.-A.Park J.-Y.Shin C.Lee H.K.Park K.S.
Ewha Authors
성연아오지영
SCOPUS Author ID
성연아scopus; 오지영scopus
Issue Date
2008
Journal Title
Diabetes Research and Clinical Practice
ISSN
0168-8227JCR Link
Citation
Diabetes Research and Clinical Practice vol. 80, no. 3, pp. 463 - 468
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Many studies show poor agreement between fasting plasma glucose (FPG)-based and 2-h postchallenge glucose (2-h PG)-based criteria to assess glucose metabolism. We examined the rate of agreement between FPG- and 2-h PG-based criteria in the diagnosis of intermediate hyperglycemia in four representative cohort studies in South Korea and compared the clinical characteristics and biochemical parameters in subjects with impaired fasting glucose (IFG) according to their FPG values. Of 6234 subjects from four population-based studies performed from 1993 to 2000, 4610 individuals with data from a 75 g oral glucose tolerance test (OGTT) and no previous history of diabetes were selected. We examined the concordance rate between the FPG and 2-h PG-based criteria. We also investigated the differences in the clinical characteristics and biochemical parameters between individuals with IFG according to their FPG values. The fasting and 2-h PG criteria had large discordance rates in the diagnosis of diabetes and impaired glucose tolerance (IGT) in Korean adults. When individuals with IFG were classified into stage 1 [5.6-6.1 mmol/L (100-109 mg/dL)] and stage 2 [6.1-7.0 mmol/L (110-125 mg/dL)] IFG, individuals with stage 2 IFG are more obese and had higher blood pressure and total cholesterol and triglycerides concentrations compared with those with stage 1 IFG. In addition, more individuals with stage 2 IFG were with diabetes as determined by a 2-h PG ≥ 11.1 mmol/L (14.1% vs. 1.9%) (P < 0.05). Considering the poorer metabolic profile and higher percentage of people with diabetes by OGTT, these data indicate that, in the Korean population, individuals with stage 2 IFG should be treated differently from those with stage 1 IFG. To detect more cases of diabetes, the OGTT is recommended for all individuals with stage 2 IFG and cases with stage 1 IFG with some additional risk factors for diabetes. © 2008 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.diabres.2008.01.022
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE