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Cultivation of Lactobacillus crispatus KLB46 isolated from human vagina

Title
Cultivation of Lactobacillus crispatus KLB46 isolated from human vagina
Authors
Chang C.E.Kim S.-C.So J.-S.Yun H.S.
Ewha Authors
김승철
SCOPUS Author ID
김승철scopus
Issue Date
2001
Journal Title
Biotechnology and Bioprocess Engineering
ISSN
1226-8372JCR Link
Citation
Biotechnology and Bioprocess Engineering vol. 6, no. 2, pp. 128 - 132
Indexed
SCIE; SCOPUS; KCI scopus
Document Type
Article
Abstract
Bacterial vaginosis can be treated by restoring the normal vaginal flora using lactobacilli. Lactobacillus crispatus KLB46 that was isolated from the human vagina has a strong antimicrobial activity and was grown in a batch and in a continuous fermentor. During batch cultivation, the maximum specific growth rate of L. crispatus KLB 46 was 0.63 h-1 and the highest viable cell count (1.9 × 109 CFU/mL) was obtained at pH 5.5. L. crispatus KLB 46 did not grow well at either pH 3.5 or 7.5. During continuous cultivation, the highest viable cell count (1.53 × 109 CFU/mL) was obtained at a dilution rate of 0.32 h-1. However, the maximum productivity of viable cells was obtained at a dilution rate of 0.52 h-1, and was 7.33 × 1011 CFU L-1 h-1, that is approximately 5 times higher than that obtained from batch culture.
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의과대학 > 의학과 > Journal papers
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