View : 21 Download: 0

Effects of vitamin antioxidants on hydroxylation of 2-acetylaminofluorene by rat liver microsomes

Title
Effects of vitamin antioxidants on hydroxylation of 2-acetylaminofluorene by rat liver microsomes
Authors
Hong Y.S.Sung N.E.Lotlikar P.D.
Ewha Authors
홍영숙
SCOPUS Author ID
홍영숙scopusscopus
Issue Date
1980
Journal Title
Korean Journal of Biochemistry
ISSN
0378-8512JCR Link
Citation
Korean Journal of Biochemistry vol. 12, no. 2, pp. 19 - 23
Indexed
SCOPUS scopus
Abstract
The effects of vitamin A acetate, vitamin A palmitate, ascorbic acid and DL-α-tocopherol in N- and ring-hydroxylation of 2-acetylaminofluorene by rat liver microsomes were examined. Vitamin A acetate at 0.1 mM inhibited both reactions almost completely whereas vitamin A palmitate at that concentration had no detectable inhibitory effects on these reactions. Ascorbic acid and DL-α-tocopherol at 0.1 mM inhibited both hydroxylations by 40-60%. Vitamin A palmitate at 1 mM showed preferential inhibition of N-hydroxylation by 40% without affecting ring-hydroxylation. These results suggest that the antioxidant property of these vitamins may be partly responsible for the inhibitory effects of these vitamins on carcinogenesis by various chemicals.
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE