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Platelet-activating factor potentiates the activity of respiratory burst and interleukin-1 in rat alveolar macrophages
- Title
- Platelet-activating factor potentiates the activity of respiratory burst and interleukin-1 in rat alveolar macrophages
- Authors
- Lee J.H.
- Ewha Authors
- 이지희
- SCOPUS Author ID
- 이지희
- Issue Date
- 1995
- Journal Title
- Korean Journal of Physiology
- ISSN
- 0300-4015
- Citation
- Korean Journal of Physiology vol. 29, no. 2, pp. 251 - 257
- Indexed
- SCOPUS
- Document Type
- Article
- Abstract
- The objective of the present study was to test the effect of platelet-activating factor (PAF) on rat alveolar macrophages. PAF alone did not stimulate superoxide secretion from alveolar macrophages. However, PAF (10-5 M) significantly enhanced phagocytic activator zymosan-induced superoxide secretion from alveolar macrophages. This enhancement of PAF plus zymosan was 30% above the sum of the separate effects of PAF and zymosan. Similarly, PAF (1.3 x 10-5 M) was not a direct stimulant of alveolar macrophages, as it had no stimulatory effect on chemiluminescence generation, but potentiated zymosan-induced activation of chemiluminescence, i.e., 162% above the separate effects of each stimulant. PAF (10-16 ~ 10-6 M) also failed to stimulate IL-1 production from alveolar macrophages. In contrast, when both PAF (10-10 M) and lipopolysaccharide (LPS) (1 μg/ml) were added together at the initiation of the culture, IL-1 production was significantly increased indicating the potentiative effects of PAF on IL-1 production by alveolar macrophages. Collectively, these data suggest that PAF alone does not activate the release of bioactive products from alveolar macrophages. However, PAF appears to act as a priming mediator that potentiates stimuli-induced macrophage activity. These novel actions of PAF prove its role as a potent mediator of inflammatory and immune responses in the lung.
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- 의과대학 > 의학과 > Journal papers
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