Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최규복 | - |
dc.date.accessioned | 2018-06-02T08:15:17Z | - |
dc.date.available | 2018-06-02T08:15:17Z | - |
dc.date.issued | 1996 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.other | OAK-16954 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/244467 | - |
dc.description.abstract | To elucidate the possibility whether an elevation of intracellular Ca2+ concentration ([Ca2+]) in rabbit coronary artery myocytes during ischemic cardioplegic period may serve as one of the mechanisms of the 'no-reflow' phenomenon or not, the changes in [Ca2+]i were measured under ischemic cardioplegia conditions using a fluorescent Ca2+ indicator, fura 2/AM. When single cells were perfused with cardioplegic or ischemic cardioplegic solutions, [Ca2+]i was significantly increased and the degree of [Ca2+]i elevation was further augmented by the ischemic cardioplegic solution. Pretreatment of a sarcoplasmic reticulum emptying agent, 20 mM caffeine, had no effect on ischemic cardioplegia-induced [Ca2+]i changes, but application of a Ca2+ channel blocker, 5 × 10-7M nifedipine, or an antagonist of Na+/Ca2+ exchange, 5 mM Ni2+, significantly inhibited the [Ca2+]i elevation, respectively. The magnitude of ischemic cardioplegia-induced [Ca2+]i elevation was dependent on the Ca2+ concentration of perfusate in the range of 0 and 2.5 mM. When Ni2+ was added to the reperfusion solution, recovery of ischemic cardioplegia-induced [Ca2+]i elevation was very rapid compared with the controls. It is concluded that ischemic cardioplegia-induced [Ca2+]i elevation may serve as one of the mechanisms of the 'no-reflow' phenomenon in rabbit coronary artery smooth muscle, cells. We propose that Na+/Ca2+ exchange may serve as a key function in ischemic cardiopelgia-induced [Ca2+]i elevation. | - |
dc.language | English | - |
dc.title | Changes in Intracellular Ca2+ Concentration of Rabbit Coronary Artery Smooth Muscle Cell during Ischemic Cardioplegic Period | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 37 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 251 | - |
dc.relation.lastpage | 261 | - |
dc.relation.journaltitle | Yonsei Medical Journal | - |
dc.identifier.scopusid | 2-s2.0-0030204070 | - |
dc.author.google | Lee Y.H. | - |
dc.author.google | Choi G.B. | - |
dc.author.google | Ahn D.S. | - |
dc.author.google | Kang B.S. | - |
dc.contributor.scopusid | 최규복(36096388100) | - |
dc.date.modifydate | 20230703145716 | - |