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Effect of recombinant bovine somatotropin (rBST) administration on residual BST and insulin-like growth factor-I levels in various tissues of cattle

Title
Effect of recombinant bovine somatotropin (rBST) administration on residual BST and insulin-like growth factor-I levels in various tissues of cattle
Authors
Choi J.Choi M.J.Kim C.Jongkyu H.A.Hong B.Ji Y.Chang B.
Ewha Authors
김춘미
SCOPUS Author ID
김춘미scopus
Issue Date
1997
Journal Title
Journal of the Food Hygienic Society of Japan
ISSN
0015-6426JCR Link
Citation
Journal of the Food Hygienic Society of Japan vol. 38, no. 4, pp. 225 - 232
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
This study was performed to investigate the effects of recombinant bovine somatotropin (rBST) administration on residual BST and insulin-like growth factor-I (IGF-I) levels in various tissues. Two experiments, (A) and (B) were conducted as follows. (A)Beef cattle (average b.w. of 450 kg) were divided into three groups control (CONT), low-dose (LOW) and high-dose HIGH groups. The CONT group received nether rBST nor vehicle. The LOW and HIGH groups were treated for 20 weeks by s.c injection with 250 mg rBST at one- week intervals and 500 mg rBST at two-week intervals, respectively. (B) Beef cattle were divided into four groups: control, (CONT) group, as described in experiment (A), and sustained-release, low-dose (SR-L), sustained-release, medium-dose (SR-M) and sustained-release, high-dose (SR-H) groups. SR-L, SR- M and SR-H were treated at two-week intervals for 24 weeks by s.c. injection with doses of 0.42 mg rBST/kg b.w. (0.08 mg rBST/kg b.w./day), 0.84 mg rBST/kg b.w. (0.06 mg rBST/kg, b.w./day) and 1.26 mg rBST/kg b.w. (0.09 mg rBST/kg b.w./day), respectively. In both experiments, animals were killed two weeks after the final treatment. In experiment A residual BST and IGF-I levels in muscle tissues of the LOW and HIGH groups were not affected by rBST administration. In experiment (B) residual BST and IGF-I levels in muscle fat liver and kidney tissues of treated groups were not different from that of the CONT group either. These results suggest that levels of BST and IGF-I n various tissues are not increased at two weeks after rBST administration.
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약학대학 > 약학과 > Journal papers
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