Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍영숙 | * |
dc.contributor.author | 박혜영 | * |
dc.date.accessioned | 2018-06-02T08:15:05Z | - |
dc.date.available | 2018-06-02T08:15:05Z | - |
dc.date.issued | 1997 | * |
dc.identifier.issn | 0378-8512 | * |
dc.identifier.other | OAK-17061 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/244385 | - |
dc.description.abstract | To investigate whether transforming growth factor α (TGFα) treatment of human ovarian cancer cells was associated with the induction of c-myc protooncogene, the expression of this gene in NIH:OVCAR-3 cells was examined. TGFα induced increase in c-myc mRNA level, with a peak after 1 h of treatment; this stimulation was dose-dependent, with an optimal concentration of 5 ng/ml TGFα. Its primary action is probably at the transcription level since the half-life of c-myc mRNA measured in the presence of actinomycin D was not modified by TGFα treatment. In addition, TGFα stimulation of c-myc mRNA did not require protein synthesis since it was not suppressed by cycloheximide treatment. Antisense phosphorothioate oligonucleotide to c-myc specifically inhibited the TGFα-stimulated c-Myc protein expression and growth of NIH:OVCAR-3 cells. Our results indicate that induction of c-myc expression by TGFα plays an important role in the growth of NIH:OVCAR-3 cells. | * |
dc.language | English | * |
dc.title | Stimulation of c-myc protooncogene expression by transforming growth factor a in human ovarian cancer cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 203 | * |
dc.relation.lastpage | 208 | * |
dc.relation.journaltitle | Experimental and Molecular Medicine | * |
dc.identifier.scopusid | 2-s2.0-0031593211 | * |
dc.author.google | Choi J.-Y. | * |
dc.author.google | Hong Y.-S. | * |
dc.author.google | Park H.-Y. | * |
dc.contributor.scopusid | 홍영숙(57218968598) | * |
dc.contributor.scopusid | 박혜영(7601567979) | * |
dc.date.modifydate | 20240301081003 | * |