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Stimulation of c-myc protooncogene expression by transforming growth factor a in human ovarian cancer cells

Title
Stimulation of c-myc protooncogene expression by transforming growth factor a in human ovarian cancer cells
Authors
Choi J.-Y.Hong Y.-S.Park H.-Y.
Ewha Authors
홍영숙박혜영
SCOPUS Author ID
홍영숙scopusscopus; 박혜영scopus
Issue Date
1997
Journal Title
Experimental and Molecular Medicine
ISSN
0378-8512JCR Link
Citation
Experimental and Molecular Medicine vol. 29, no. 4, pp. 203 - 208
Indexed
SCOPUS scopus
Document Type
Article
Abstract
To investigate whether transforming growth factor α (TGFα) treatment of human ovarian cancer cells was associated with the induction of c-myc protooncogene, the expression of this gene in NIH:OVCAR-3 cells was examined. TGFα induced increase in c-myc mRNA level, with a peak after 1 h of treatment; this stimulation was dose-dependent, with an optimal concentration of 5 ng/ml TGFα. Its primary action is probably at the transcription level since the half-life of c-myc mRNA measured in the presence of actinomycin D was not modified by TGFα treatment. In addition, TGFα stimulation of c-myc mRNA did not require protein synthesis since it was not suppressed by cycloheximide treatment. Antisense phosphorothioate oligonucleotide to c-myc specifically inhibited the TGFα-stimulated c-Myc protein expression and growth of NIH:OVCAR-3 cells. Our results indicate that induction of c-myc expression by TGFα plays an important role in the growth of NIH:OVCAR-3 cells.
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의과대학 > 의학과 > Journal papers
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