Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한운섭 | * |
dc.contributor.author | 박응범 | * |
dc.contributor.author | 김광호 | * |
dc.contributor.author | 이선영 | * |
dc.date.accessioned | 2018-06-02T08:15:02Z | - |
dc.date.available | 2018-06-02T08:15:02Z | - |
dc.date.issued | 1998 | * |
dc.identifier.issn | 1011-8934 | * |
dc.identifier.other | OAK-17084 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/244369 | - |
dc.description.abstract | We have examined the serum levels of the mutant p53 protein in patients with colorectal cancer preoperatively (n=50), and in patients with adenomatous polyp (n=13). Mutant p53 protein in patients after curative surgical resection of colorectal cancer (n=26, part of the fifty preoperative patients) was also measured. Serum samples were stored frozen at -70°C until the time of analysis. We used the p53 mutant ELISA (QIA03, CALBIOCHEM) system. Serum levels of the mutant p53 protein in patients with colorectal cancer (mean=0.97±0.14 ng/ml, ranged from 0.7 ng/ml to 1.37 ng/ml, n=50) were significantly greater than those in patients with adenomatous polyp (mean=0.73±0.06 ng/ml, ranged from 0.69 ng/ml to 0.83 ng/ml) (p<0.001). There was a significant correlation between serum p53 levels and CA19-9 levels (p<0.01). Serum levels of the mutant p53 protein prior to surgery (mean=0.97±0.13 ng/ml, n=26) significantly decreased after surgical resection of tumor (mean=0.82±0.07 ng/ml) (p<0.001, paired t-test). These results suggest that mutant p53 protein might be used as a potential biomarker in the management of patients with colorectal cancer. Further study is warranted to establish its clinical significance. Copyright © The Korean Academy of Medical Sciences. | * |
dc.language | English | * |
dc.title | Increased serum levels of mutant p53 proteins in patients with colorectal cancer | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 44 | * |
dc.relation.lastpage | 48 | * |
dc.relation.journaltitle | Journal of Korean Medical Science | * |
dc.identifier.scopusid | 2-s2.0-0031992945 | * |
dc.author.google | Shim K.-S. | * |
dc.author.google | Kim K.-H. | * |
dc.author.google | Park B.-W. | * |
dc.author.google | Lee S.-Y. | * |
dc.author.google | Choi J.-H. | * |
dc.author.google | Han W.-S. | * |
dc.author.google | Park E.-B. | * |
dc.contributor.scopusid | 한운섭(7401899962;24172227800) | * |
dc.contributor.scopusid | 박응범(56059292000) | * |
dc.contributor.scopusid | 김광호(57192983544) | * |
dc.contributor.scopusid | 이선영(7201404669;56218479400) | * |
dc.date.modifydate | 20240423081003 | * |