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Functional maturation of myeloid cells during in vitro differentiation from human cord blood CD34+ cells

Title
Functional maturation of myeloid cells during in vitro differentiation from human cord blood CD34+ cells
Authors
Jung Y.-J.Woo S.-Y.Ryu K.-H.Chung W.-S.Kie J.-H.Seoh J.-Y.
Ewha Authors
서주영정화순유경하우소연
SCOPUS Author ID
서주영scopus; 정화순scopus; 유경하scopus; 우소연scopus
Issue Date
2002
Journal Title
Haematologica
ISSN
0390-6078JCR Link
Citation
Haematologica vol. 87, no. 11, pp. 1222 - 1223
Indexed
SCI; SCIE; SCOPUS scopus
Document Type
Article
Abstract
CD34+ cells purified from human cord blood were expanded in the presence of several cytokines. The cultured cells were assayed for myeloid effector functions, including phagocytic activity, respiratory burst and microbicidal activity. The results showed that phagocytic activity was observed as early as day 6, irrespective of the type of cytokines used. By contrast, respiratory burst and microbicidal activity peaked on day 15 and were dependent on the type of cytokines used. In particular, granulocyte-colony stimulating factor and interleukin-6 markedly enhanced respiratory burst and microbicidal activity.
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의과대학 > 의학과 > Journal papers
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