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Circulating cytokine levels and changes during the treatment in patients with active tuberculosis in Korea

Title
Circulating cytokine levels and changes during the treatment in patients with active tuberculosis in Korea
Authors
Ryu Y.-J.Kim Y.-J.Kwon J.-M.Na Y.-J.Jung Y.-J.Seoh J.Y.Cheon S.H.
Ewha Authors
서주영류연주
SCOPUS Author ID
서주영scopus; 류연주scopus
Issue Date
2003
Journal Title
Tuberculosis and Respiratory Diseases
ISSN
0378-0066JCR Link
Citation
vol. 55, no. 2, pp. 140 - 153
Indexed
SCOPUS scopus
Abstract
Background: The cell-mediated immune reaction to tuberculosis infection involves a complex network of cytokines. The extent of inflammation, tissue damage and severity of the disease suggested to be determined by the balance between extent and duration of the proinflammatory cytokine response versus those of the suppressive cytokines. The systemic cytokine response in pathogenesis of tuberculosis can be assessed by measuring serum cytokine levels. Method: Serum interleukin-1 beta(IL-1β), IL-2, IL-4, IL-6, IL-10, IL-12(p40), tumor necrosis factor-alpha(TNF-α), interferon-gamma(IFN-γ) and transforming growth factor-beta(TGF-β) levels were measured in 83 patients with pulmonary tuberculosis, 10 patients with endobronchial tuberculosis before treatment and 20 healthy subjects by using a sandwich ELISA. In patients with pulmonary tuberculosis, they were divided into mild, moderate and far advanced group according to the severity by ATS guidelines. To compare with those of pretreatment levels, we measured serum IL-10, IL-2, IL-4, IL-6, IL-10, IL-12(p40), TNF-α, IFN-γ and TGF-β levels in 45 of 83 patients with pulmonary tuberculosis after 2 and 6 months of treatment. Results: 1) In sera of patients with active pulmonary tuberculosis(n=83), IL-1β, IL-6(p<0.05), TNF-α, and IFN-γ were elevated and TGF-β was decreased comparing to control. IL-2, IL-12(p40), IL-4 and IL-10 were similar between the patients with tuberculosis and control. 2) In endobronchial tuberculosis, IL-6 and TNF-α were elevated and TGF-β was decreased comparing to control. IL-12(p40) seemed to be elevated comparing to pulmonary tuberculosis. 3) Far advanced tuberculosis showed markedly elevated IL-6 and IFN-γ level(p<0.05). 4) The significant correlations were noted between IL-1, IL-6 and TNF-α and between IL-12, IL-2 and IL-4(p<0.01). 5) After 2 and 6 months of standard treatment, the level of IL-6 and IFN-γ was significantly decreased(p<0.05). Conclusion: These results showed that an altered balance between cytokines is likely to be involved in the extent of inflammation, tissue damage and severity of the disease tuberculosis. But, it should be considered diversities of cytokine response according to type of tuberculosis and immunity in clinical application and interpreting future studies.
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의과대학 > 의학과 > Journal papers
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