View : 595 Download: 0
Overexpression of c-ErbB-2 protein in gastric cancer by immunohistochemical stain
- Title
- Overexpression of c-ErbB-2 protein in gastric cancer by immunohistochemical stain
- Authors
- Lee H.R.; Kim J.-H.; Uhm H.D.; Ahn J.B.; Rha S.Y.; Cho J.Y.; Lee J.I.; Lee K.H.; Chung H.C.; Roh J.K.; Min J.S.; Lee K.S.; Shin D.H.; Kim B.S.; Hong S.W.; Choi J.-H.
- Ewha Authors
- 최진혁
- Issue Date
- 1996
- Journal Title
- Oncology
- ISSN
- 0030-2414
- Citation
- Oncology vol. 53, no. 3, pp. 192 - 197
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML