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dc.contributor.author박혜영-
dc.date.accessioned2018-06-02T08:14:30Z-
dc.date.available2018-06-02T08:14:30Z-
dc.date.issued1996-
dc.identifier.issn1016-8478-
dc.identifier.otherOAK-17499-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/244158-
dc.description.abstractWe have used both quantitative autoradiography to localize in rat brain beta-1 and beta-2 adrenergic receptors and in situ hybridization to detect expression of beta-1 adrenergic receptor mRNA in rat brain. The receptors were labeled in vitro with 3H-dihydroalprenolol (3H-DIIA) that binds nonselectively to both beta-1 and beta-2 receptor subtypes. Selective inhibition of 3H-DHA binding with specific antagonists of beta-1 and beta-2 receptors allowed the visualization of beta-adrenergic receptor subtypes. High levels of beta-1 receptors were observed in the cingulate cortex, layers I-III of the cerebral cortex, hippocampus, and thalamus. Oligonucleotide labeled with 35S-dATP was used for in situ hybridization. High levels of beta-2 receptors were found in the cerebellum. Approximately equal levels of beta-1 and beta-2 receptors occurred in the midbrain including substantia nigra. The hybridization signal for beta-1 mRNA was strongest in cingulate and piriform cortex, thalamic nuclei and light or moderate in somatosensory cortex and hippocampus. The pronounced differences in the ratio of beta-1 to beta-2 receptors among brain .regions suggests that the subtypes of beta-adrenergic receptors may play different roles in neuronal function. © 1996 The Korean Society for Molecular Biology.-
dc.languageEnglish-
dc.titleQuantitative autoradiography of beta-1 and beta-2 adrenergic receptor and cellular localization of mRNA for beta-1 adrenergic receptor in rat brain-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume6-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage456-
dc.relation.lastpage462-
dc.relation.journaltitleMolecules and Cells-
dc.identifier.scopusid2-s2.0-21944448860-
dc.author.googlePark H.-Y.-
dc.author.googlePark K.-H.-
dc.author.googleKim Y.-S.-
dc.author.googleShin S.-G.-
dc.author.googleChung M.-H.-
dc.author.googlePark C.-W.-
dc.contributor.scopusid박혜영(7601567979)-
dc.date.modifydate20180601110533-
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의과대학 > 의학과 > Journal papers
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