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Haemophilus influenzae and human herpes virus-6 detection by EIA and PCR in CSF from young hospitalized children with aseptic meningitis

Title
Haemophilus influenzae and human herpes virus-6 detection by EIA and PCR in CSF from young hospitalized children with aseptic meningitis
Authors
Lee S.-J.Park H.-K.Woo S.-Y.Shin Y.-J.Ahn S.-H.
Ewha Authors
박혜경이승주우소연
SCOPUS Author ID
박혜경scopus; 이승주scopusscopus; 우소연scopus
Issue Date
2002
Journal Title
Journal of Bacteriology and Virology
ISSN
1598-2467JCR Link
Citation
Journal of Bacteriology and Virology vol. 32, no. 4, pp. 331 - 337
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
There are various microbial agents which causing meningitis in children. It is well known that Haemophilus influenzae (HI) are the most frequent bacterial agents. In Korea, it is hard to find studies detecting HI in cerebrospinal fluid (CSF) from pediatric patients with aseptic meningitis by PCR. It has been also reported that human herpes virus-6 (HHV-6) causes meningitis, meningoencephalitis, neuroinvasion and persistent infection of the central nervous system in children. In this study we also detected HHV-6 in the same CSF by EIA and PCR. We used 85 CSF specimens from 85 aseptic meningitis patients (mean age 6.6 years) taken from the Department of Pediatrics at Ewha Womans University MokDong Hospital from June 2001 to August 2002. Detection rate of HI by EIA method was 12.9% (11/85) and by PCR was 16.5% (14/85). Detection rate of HHV-6 by EIA and by PCR was 18.8% (16/85) and 21.2% (18/85), respectively. Co-detection rate of HI and HHV-6 was 7.1% (6/85) by EIA and 12.9% (11/85) by PCR. In conclusion, by PCR in combination with EIA, HI infection could be proved in the aseptic meningitis CSF from which no bacterium was cultivated.
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의과대학 > 의학과 > Journal papers
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