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Anti-inflammatory effect of unripe fruit of Citrus grandis Osbeck in RAW264.7 and HaCaT cells

Title
Anti-inflammatory effect of unripe fruit of Citrus grandis Osbeck in RAW264.7 and HaCaT cells
Authors
Lee H.-J.Kang G.-J.Yoon W.-J.Kang H.-K.Kim Y.-S.Kim S.-M.Yoo E.-S.
Ewha Authors
김영석
SCOPUS Author ID
김영석scopus
Issue Date
2006
Journal Title
Korean Journal of Pharmacognosy
ISSN
0253-3073JCR Link
Citation
Korean Journal of Pharmacognosy vol. 37, no. 2, pp. 74 - 80
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
We investigated the anti-inflammatory activities of unripe fruit of Citrus grandis Osbeck growing at Jeju Island, through the evaluation of their inhibitory effect on the production of inflammatory markers (IL-6, iNOS, COX, TARC and MDC) in RAW264.7 murine macrophage cells and HaCaT human keratinocyte cells. Among the sequential solvent fractions obtained from crude extract, hexane and chloroform (CHCl3) fractions showed potential inhibitory activity on the mRNA expressions of IL-6, iNOS and COX-2 at the concentration of 100 μg/ml in RAW264.7 cells. Also, EtOAc fraction showed inhibitory activity on the thymus and activation-regulated chemokine (TARC)/CCL17 and macrophage-derived chemokine (MDC)/CCL22 at the concentration of 50 μg/ml in HaCaT cells. These results suggest that the unripe fruit of C. grandis may have anti-inflammatory activity through the suppression of inflammatory markers (IL-6, iNOS, COX, TARC and MDC).
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엘텍공과대학 > 식품공학전공 > Journal papers
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