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Lack of association between serum leptin levels and hepatic steatosis, fibrosis or response to antiviral therapy in Korean chronic hepatitis C patients

Title
Lack of association between serum leptin levels and hepatic steatosis, fibrosis or response to antiviral therapy in Korean chronic hepatitis C patients
Authors
Gwak G.-Y.Tae H.K.Su J.Y.Yoon J.-H.Yong J.J.Su C.P.Lee H.-S.
Ewha Authors
김태헌
SCOPUS Author ID
김태헌scopus
Issue Date
2007
Journal Title
Hepato-Gastroenterology
ISSN
0172-6390JCR Link
Citation
Hepato-Gastroenterology vol. 54, no. 75, pp. 844 - 848
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
Background/Aims: Leptin has been recently implicated in the development of hepatic steatosis and fibrosis in chronic hepatitis C (CHC) infection. The serum levels of leptin are known to be strongly affected by anthropometric parameters such as body mass index (BMI) and total body fat, which show differences between races or ethnicities. In this study, we examined whether serum leptin levels are correlated with clinical, virological, and histological features, and with response to antiviral therapy in Korean CHC patients. Methodology: We evaluated correlations between serum leptin level and age, sex, BMI, fasting glucose, alanine aminotransferase, genotype, hepatitis C virus RNA titer, steatosis, fibrosis, and response to antiviral therapy after 24 weeks completing 24 weeks of interferon-α based therapy in 47 Korean CHC patients. Results: Of the variables examined, only female sex and a BMI >25kg/m 2 were identified as independent variables related to a higher leptin level by multivariate analysis. Baseline leptin levels and leptin changes before/after antiviral therapy were not correlated with response to therapy. Conclusions: In Korean CHC patients, serum leptin levels were found to be correlated with anthropometric parameters, but not with virological or histological features. In addition, serum leptin levels did not predict response to antiviral therapy. © H.G.E. Update Medical Publishing S.A.
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의과대학 > 의학과 > Journal papers
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