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Leptin is associated with endothelial dysfunction in healthy obese premenopausal women

Title
Leptin is associated with endothelial dysfunction in healthy obese premenopausal women
Authors
Kwon K.Choi K.Park S.-H.
Ewha Authors
박시훈권기환
SCOPUS Author ID
박시훈scopus; 권기환scopus
Issue Date
2007
Journal Title
Korean Circulation Journal
ISSN
1738-5520JCR Link
Citation
Korean Circulation Journal vol. 37, no. 6, pp. 251 - 257
Indexed
SCIE; SCOPUS; KCI scopus
Document Type
Article
Abstract
Background and Objectives : Previous studies have demonstrated that adipokines can have positive and/or negative effects on vascular function. In this study, we attempted to characterize the association of adipokines with endothelium-dependent vasodilation in healthy premenopausal women. Subjects and Methods : Noninvasive pulse wave analysis coupled with provocative pharmacological testing with salbutamol was used to measure endothelium- dependent vasodilation in 60 healthy premenopausal women [37 obese women; body mass index (BMI) > 25 kg/m2, 23 age-matched non-obese women; BMI<25 kg/m2]. The lipid profile, fasting insulin, glucose, and C-reactive protein (CRP) concentrations in each patient were assessed via standard laboratory techniques, and plasma concentrations of various adipokines, such as adiponectin, leptin, resistin and TNF-α, were measured via enzyme immunoassays. Results : In the obese group, higher leptin concentrations were significantly associated with impairments in endothelium-dependent vasodilation (r=-0.371, p=0.005). This association remained significant, even after adjustment for other risk factors (β3=-0.39, p=0.006). However, we determined that there was no significant correlation between endothelium-dependent vasodilation and these variables in the obese group and the control group. Conclusion : Increased plasma concentration of leptin was associated with impairment in endothelial function in obese premenopausal women, regardless of the metabolic and inflammatory disturbances associated with obesity. © 2007, The Korean Society of Circulation.
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의과대학 > 의학과 > Journal papers
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