Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이서구 | * |
dc.contributor.author | 정우진 | * |
dc.contributor.author | 우현애 | * |
dc.date.accessioned | 2018-06-02T08:13:58Z | - |
dc.date.available | 2018-06-02T08:13:58Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0098-6577 | * |
dc.identifier.other | OAK-17850 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243945 | - |
dc.description.abstract | Peroxiredoxin (Prx) is a family of bifunctional proteins that exhibit peroxidase and chaperone activities. Prx proteins contain a conserved Cys residue that undergoes a redox change between thiol and disulfide states. 2-Cys Prx enzymes, a subgroup of Prx family, are intrinsically susceptible to reversible hyperoxidation to cysteine sulfinic acid during catalysis. Cysteine hyperoxidation of Prx was shown to result in loss of peroxidase activity and a concomitant gain of chaperone activity. Reduction of sulfinic Prx enzymes, the first known biological example of such a reaction, is catalyzed by sulfiredoxin (Srx) in the presence of ATP. Srx appears to exist solely to support the reversible sulfinic modification of 2-Cys Prx enzymes. Srx specifically binds to 2-Cys Prx enzymes by recognizing several critical surface-exposed residues of the Prxs, and transfer the gamma-phosphate of ATP to their sulfinic moiety, using its conserved cysteine as the phosphate carrier. The resulting sulfinic phosphoryl ester is reduced to cysteine after oxidation of four thiol equivalents. | * |
dc.language | English | * |
dc.title | Sulfiredoxin, the cysteine sulfinic acid reductase specific to 2-Cys peroxiredoxin: its discovery, mechanism of action, and biological significance. | * |
dc.type | Review | * |
dc.relation.issue | 106 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | S3 | * |
dc.relation.lastpage | 8 | * |
dc.relation.journaltitle | Kidney international. Supplement | * |
dc.identifier.scopusid | 2-s2.0-35348841031 | * |
dc.author.google | Rhee S.G. | * |
dc.author.google | Jeong W. | * |
dc.author.google | Chang T.S. | * |
dc.author.google | Woo H.A. | * |
dc.contributor.scopusid | 이서구(7401852092) | * |
dc.contributor.scopusid | 정우진(35914322500) | * |
dc.contributor.scopusid | 우현애(8068619500) | * |
dc.date.modifydate | 20240423081003 | * |